MS-061: Structure-guided protein design/engineering in biomedicine and biotechnology I

Co-Chairs: Igor Polikarpov & Vanita Sood

Sponsoring Commission: Biological Macromolecules

Structure-guided protein design and engineering are opening new frontiers in biomedicine and biotechnology by enabling the creation of molecules with functions not represented in nature. Approaches such as inverse folding, backbone design, protein inpainting, scaffolding for designed active sites, and engineering protein surfaces for binding or catalysis are driving innovation in biologics and therapeutic proteins. This microsymposium will highlight recent advances in computational design, experimental strategies, and structural characterization that expand the boundaries of molecular functionality, demonstrating how engineered proteins can address challenges in medicine, biotechnology, and materials science.