MOOT 37 NMR Symposium

Protein-Protein Interactions (PPIs) are the Holy Grail of therapeutic intervention, offering a plethora of unique structural landscapes as potential targets. The Arthanari Lab uses structure-guided approaches to characterize and validate PPIs in the context of disease models.  The lab utilizes a combination of techniques including NMR spectroscopy, NMR-based fragment and high throughput screening, and biophysical and cell-based assays to map hotspots in the interaction interface, to further understand the molecular mechanisms orchestrated by these interactions, and to identify disruptive inhibitors that may be developed into treatments for the related pathologies. 

The Kay Lab is committed to the study of complex biological systems using novel NMR methodologies. Our diverse working environment fosters creativity and innovation, allowing us to push scientific boundaries.  The laboratory focuses on understanding the molecular determinants of phase separation using NMR spectroscopy. The overarching goal of the group is to illustrate the critical role of molecular dynamics in regulating biological processes.

The Gauthier lab is interested in developing new analytical approaches to investigate anthropogenic compounds in the environment and living species. The instrument of choice for the Gauthier lab is Nuclear Magnetic Resonance (NMR) spectroscopy, a uniquely powerful tool for the analysis of fluorinated and phosphorylated compounds, including per- and polyfluorinated alkyl substances (PFAS). Key research themes include:

1. Development and application of NMR-based approaches to better understand the true extent of anthropogenic fluorine contamination in environmental and biological samples.

2. Investigation of the behaviour and fate of fluorine-containing compounds in plants, animals, humans, and the environment.