Download a more compact version of the Conference Program as of 8/21/21 HERE
Please note that there is an open call from the editors at Anaerobe for paper submissions for a Special Issue on ClostPath 12. Submissions would describe work presented at ClostPath 12. The deadline for submission is April 1, 2022. See this link for details. Please also email clostpath2021@gmail.com if you are interested in contributing an article to this Special Issue.
Virtual Clostpath 2021 Schedule
Times listed are EDT (e.g. Boston/ East Coast)
For a printable schedule with times for Europe and Australia, download the pdf at the TOP of the page
Monday, September 13 Young Scientist Pre-meeting
3:30 - 4:45 PM (9:30 PM Munich, 5:30 AM+1 Melbourne)
Monday, September 13 (5 PM Boston, 11 PM Munich, 7 AM Melbourne)
5:00 - 5:05 PM Welcome (Drs. Borden Lacy & Aimee Shen) & Introduction to Keynote Lecturer (Dr. Bruce McClane)
5:05 - 5:35 PM Keynote Lecture: Dr. Julian Rood, Monash University, Australia.
The conjugative plasmid-toxin nexus in Clostridium perfringens
Session I: Session Chair - Dr. Xingmin Sun, University of South Florida, USA
5:35 - 5:47 PM Short Talk - Dr. Jihong Li, University of Pittsburgh, USA
NanH is Produced by Sporulating Cultures of Clostridium perfringens Type F Food Poisoning Strains and Enhances the Cytotoxicity of C. perfringens Enterotoxin
5:48 - 6:00 PM Short Talk - Dr. Mauricio Navarro, University of California Davis
Paeniclostridium sordellii-associated metritis in goats
6:00 - 6:25 PM Dr. Daniel Knight, Murdoch University, Australia
New evolutionary and ecological insights into the Clostridioides difficile species
6:25 - 6:37 PM Short Talk - Shailab Shrestha, Tufts University School of Medicine, USA
Clostridioides difficile uses distinct cell division machineries during spore formation and vegetative growth
6:37 - 6:50 PM Short Talk - Dr. Steven Melville, Virginia Tech, USA
Secretion of the large clostridial toxin TpeL from Clostridium perfringens requires a holin protein, TpeE, that is similar to the Twin-Arginine Transport protein TatA
7:00 - 8:00 PM ClostPath 12 - Social Event (Zoom-based)
Tuesday, September 14 (9 AM Boston, 3 PM Munich, 11 PM Melbourne)
Session II: Session Chair - Dr. Erin Purcell, Old Dominion University, USA
9:00 - 9:25 AM State-of-the-Art Lecture: Dr. Rita Tamayo, University of North Carolina, USA
Mechanisms and consequences of phenotypic heterogeneity in Clostridioides difficile
9:25 - 9:50 AM Dr. Shonna McBride, Emory University, USA
Spo0E regulates cellular differentiation, motility, and virulence in Clostridioides difficile
9:50 - 10:02 AM Short Talk - Leslie Ronish, University of Nebraska-Lincoln, USA
Molecular mechanisms of Clostridioides difficile biofilm formation
10:02 - 10:15 AM Short Talk - Dr. Yannick Tremblay, University of Saskatchewan, Canada
Extracellular pyruvate induces biofilm formation in Clostridioides difficile
10:15 - 10:40 AM Dr. Isabelle Martin-Verstraete, Université de Paris, France
Know your enemy: how anaerobic Clostridioides difficile deals with low O2 tensions
10:40 - 10:50 AM Break
Session III: Session Chair - Dr. Lisa Dawson, London School of Tropical Medicine, United Kingdom
10:50 - 11:15 AM Dr. Francisco Uzal, University of California, Davis, USA
The story of NanI sialidase of Clostridium perfringens
11:15 – 11:27 AM Short Talk - Dr. Mostafa Abdel-Gli, Friedrich-Loeffler-Institute, Germany
Stable phylogroups of Clostridium perfringens revealed by a comparative in silico genome analysis
11:28 – 11:40 AM Short Talk - Dr. Johann Peltier, Université Paris-Saclay, France
Type I toxin-antitoxin systems contribute to the maintenance of mobile genetic elements maintenance in Clostridioides difficile
11:40 – 11:52 AM Short Talk - Dr. Franziska Faber, University of Würzburg, Germany
Functional analysis of the RNA landscape in C. difficile reveals a global RNA-binding protein that regulates toxin production
11:53 – 12:05 PM Short Talk - Dr. Kathryn Cherny, Northwestern University, USA
Characterization of structure and function of a Clostridium innocuum hypothetical protein that is cross-reactive with Clostridioides difficile anti-toxin antibodies
12:05 - 12:10 PM Flash Talk - Daniel Troitzsch, University of Greifswald, Germany
A Point Mutation in the Transcriptional Repressor PerR Results in a Constitutive Oxidative Stress Response in Clostridioides difficile 630Δerm
12:10 - 12:15 PM Flash Talk - Ajitha Sundaresan, Temasek Life Sciences Laboratory, Singapore
A germination interaction study of Clostridium novyi-NT spores reveals a novel non-canonical D-Amino acid germinant
12:15 - 12:20 PM Flash Talk - Dr. PJ Hensbergen, Leiden University Medical Center, the Netherlands
Novel insights in the structure and biosynthesis of the Clostridioides difficile flagellin C (FliC) Type A modification
12:20 – 12:30 PM Break
12:30 - 1:30 PM Poster Session I – Live on Symposium (Asynchronous viewing possible)
symposium.foragerone.com/clostpath-12
Wednesday, September 15 (9 AM Boston, 3 PM Munich, 11 PM Melbourne)
Session IV: Session Chair - Dr. Chris Lopez, California State University, Sacramento
9:00 – 9:25 AM State-of-the-Art Lecture: Dr. Roman Melnyk (Toxins Sponsored Speaker), University of Toronto, Canada
Unraveling the role of intestinal bile acids in modulating C. difficile TcdB structure & function
9:25 - 9:50 AM Dr. Sabine Pellett, University of Wisconsin Madison, USA
Post-translational regulation of botulinum neurotoxin production in Clostridium botulinum Hall A-hyper
9:50 - 10:02 AM Short Talk - Dr. Christopher Peritore-Galve, Vanderbilt University, USA
Glucosyltransferase-independent effects of toxins A and B in the mouse model of C. difficile infection
10:03 - 10:15 AM Short Talk - Dr. Rongshen Jin, University of California, Irvine, USA
Structural basis for CSPG4 as a key receptor and therapeutic target for C. difficile toxin B
10:15 - 10:40 AM Dr. Brigitte Dorner, Robert Koch-Institut, Germany
Botulinum neurotoxins: New findings on receptor binding and how they translate into innovative detection approaches.
10:40 - 10:50 AM Break
Session V: Session Chair - Dr. Meera Unnikrishnan, Warwick University, United Kingdom
10:50 - 11:15 AM Dr. Julian Hurdle, Texas A&M University, USA.
How C. difficile evolves resistance to first-line drugs and its impact on patient care and global epidemiology.
11:15 – 11:40 AM Dr. Wiep Klaas Smits, Leiden University Medical Center
DNA replication in Clostridioides difficile, a potential target for antimicrobials
11:40 – 11:52 AM Short Talk - Dr. Jason Wilson, University of Sheffield, United Kingdom
CryoEM structure and structural characterisation of a Clostridioides difficile Myovirus phage
11:52 – 12:00 PM Short Talk - Dr. Horst Posthaus, University of Bern, Switzerland
News from the dark side (of the gut): Receptor specificity and function of Clostridium perfringens beta-toxin
12:05 – 12:10 PM Flash Talk - Anthony Pannullo, University of Iowa, USA
The Novel Two-Component System DraRS and its Role in Daptomycin Resistance in C. difficile
12:10 - 12:15 PM Flash Talk - Dr. Iman Mehdizadeh Gohari, University of Pittsburg, USA
Identifying the basis for VirS/VirR two-component regulatory system control of Clostridium perfringens beta toxin production
12:15 - 12:20 PM Flash Talk - Dr. Deiziane Viana da Silva Costa, University of Virginia, USA
Adenosine receptors differentially mediate enteric glial cell death induced by Clostridioides difficile toxins A and B
12:20 – 12:30 Break
12:30 - 1:30 PM Poster Session II – Live on Symposium (Asynchronous viewing possible)
Thursday, September 16 (9 AM Boston, 3 PM Germany, 11 PM Melbourne)
Session VI: Session Chair - Dr. Andrew Hryckowian, University of Wisconsin, Madison, USA
9:00 – 9:25 AM State-of-the-Art Lecture: Dr. Eric Skaar, Vanderbilt University Medical Center, USA.
Clostridioides difficile strategies to survive nutrient metal deprivation and excess.
9:25- 9:50 AM Dr. Lynn Bry, Brigham and Women’s Hospital, USA
Commensal control of C. difficile virulence.
9:50 - 10:02 AM Short Talk - Andrea Martinez Aguirre, University of Texas A&M, USA
Bile acid independent protection against C. difficile infection
10:03 - 10:15 AM Short Talk - Germán Vargas-Cuebas, Emory University School of Medicine, USA
Impact of glycine Stickland metabolism on Clostridioides difficile pathogenesis and its regulation in response to the host peptide LL-37
10:15 - 10:40 AM Dr. Nobuhiko Kamada, University of Michigan, USA
Microbe-metabolite-host interactions in the protection against Clostridioides difficile infection
10:40 - 10:50 AM Break
Session VII: Session Chair - Dr. Michael Abt, University of Pennsylvania, USA
10:50 - 11:15 AM Dr. Simon Hirota, University of Calgary, Canada
The interplay between neutrophils and innate lymphoid cells during TcdA/B-induced intestinal injury
11:15– 11:27 AM Short Talk - Dr. Zahidul Alam, University of Pennsylvania Perelman School of Medicine, USA
IL-10 producing regulatory T cells limits type 1 inflammation during persistent C. difficile infection and supports fecal microbiota transplantation engraftment
11:27 – 11:40 AM Short Talk - Dr. Esther Duperchy, Summit Therapeutics, United Kingdom
Metagenomic analysis of the impact of the precision antibiotic ridinilazole, compared to vancomycin, on the gut resistome in a Phase 2 study
11:40 – 12:05 PM Dr. Thomas Louie, University of Calgary School of Medicine, Canada
Fecal Microbiota Transplantation for recurrent CDI: Fine tuning and a paradigm shift improves safety and retains efficacy
12:05 – 12:15 PM Concluding Remarks
12:15 – 12:30 PM Break
12:30 – 2:00 PM Career Panel Discussion, Young Scientist's Meeting continued
