Download a more compact version of the Conference Program as of 8/21/21 HERE

Please note that there is an open call from the editors at Anaerobe for paper submissions for a Special Issue on ClostPath 12. Submissions would describe work presented at ClostPath 12. The deadline for submission is April 1, 2022. See this link for details. Please also email if you are interested in contributing an article to this Special Issue.

Virtual Clostpath 2021 Schedule

Times listed are EDT (e.g. Boston/ East Coast)

For a printable schedule with times for Europe and Australia, download the pdf at the TOP of the page

Monday, September 13 Young Scientist Pre-meeting

3:30 - 4:45 PM (9:30 PM Munich, 5:30 AM+1 Melbourne)

Monday, September 13 (5 PM Boston, 11 PM Munich, 7 AM Melbourne)

5:00 - 5:05 PM Welcome (Drs. Borden Lacy & Aimee Shen) & Introduction to Keynote Lecturer (Dr. Bruce McClane)

5:05 - 5:35 PM Keynote Lecture: Dr. Julian Rood, Monash University, Australia.

The conjugative plasmid-toxin nexus in Clostridium perfringens

Session I: Session Chair - Dr. Xingmin Sun, University of South Florida, USA

5:35 - 5:47 PM Short Talk - Dr. Jihong Li, University of Pittsburgh, USA

NanH is Produced by Sporulating Cultures of Clostridium perfringens Type F Food Poisoning Strains and Enhances the Cytotoxicity of C. perfringens Enterotoxin

5:48 - 6:00 PM Short Talk - Dr. Mauricio Navarro, University of California Davis

Paeniclostridium sordellii-associated metritis in goats

6:00 - 6:25 PM Dr. Daniel Knight, Murdoch University, Australia

New evolutionary and ecological insights into the Clostridioides difficile species

6:25 - 6:37 PM Short Talk - Shailab Shrestha, Tufts University School of Medicine, USA

Clostridioides difficile uses distinct cell division machineries during spore formation and vegetative growth

6:37 - 6:50 PM Short Talk - Dr. Steven Melville, Virginia Tech, USA

Secretion of the large clostridial toxin TpeL from Clostridium perfringens requires a holin protein, TpeE, that is similar to the Twin-Arginine Transport protein TatA

7:00 - 8:00 PM ClostPath 12 - Social Event (Zoom-based)

Tuesday, September 14 (9 AM Boston, 3 PM Munich, 11 PM Melbourne)

Session II: Session Chair - Dr. Erin Purcell, Old Dominion University, USA

9:00 - 9:25 AM State-of-the-Art Lecture: Dr. Rita Tamayo, University of North Carolina, USA

Mechanisms and consequences of phenotypic heterogeneity in Clostridioides difficile

9:25 - 9:50 AM Dr. Shonna McBride, Emory University, USA

Spo0E regulates cellular differentiation, motility, and virulence in Clostridioides difficile

9:50 - 10:02 AM Short Talk - Leslie Ronish, University of Nebraska-Lincoln, USA

Molecular mechanisms of Clostridioides difficile biofilm formation

10:02 - 10:15 AM Short Talk - Dr. Yannick Tremblay, University of Saskatchewan, Canada

Extracellular pyruvate induces biofilm formation in Clostridioides difficile

10:15 - 10:40 AM Dr. Isabelle Martin-Verstraete, Université de Paris, France

Know your enemy: how anaerobic Clostridioides difficile deals with low O2 tensions

10:40 - 10:50 AM Break

Session III: Session Chair - Dr. Lisa Dawson, London School of Tropical Medicine, United Kingdom

10:50 - 11:15 AM Dr. Francisco Uzal, University of California, Davis, USA

The story of NanI sialidase of Clostridium perfringens

11:15 – 11:27 AM Short Talk - Dr. Mostafa Abdel-Gli, Friedrich-Loeffler-Institute, Germany

Stable phylogroups of Clostridium perfringens revealed by a comparative in silico genome analysis

11:28 – 11:40 AM Short Talk - Dr. Johann Peltier, Université Paris-Saclay, France

Type I toxin-antitoxin systems contribute to the maintenance of mobile genetic elements maintenance in Clostridioides difficile

11:40 – 11:52 AM Short Talk - Dr. Franziska Faber, University of Würzburg, Germany

Functional analysis of the RNA landscape in C. difficile reveals a global RNA-binding protein that regulates toxin production

11:53 – 12:05 PM Short Talk - Dr. Kathryn Cherny, Northwestern University, USA

Characterization of structure and function of a Clostridium innocuum hypothetical protein that is cross-reactive with Clostridioides difficile anti-toxin antibodies

12:05 - 12:10 PM Flash Talk - Daniel Troitzsch, University of Greifswald, Germany

A Point Mutation in the Transcriptional Repressor PerR Results in a Constitutive Oxidative Stress Response in Clostridioides difficile 630Δerm

12:10 - 12:15 PM Flash Talk - Ajitha Sundaresan, Temasek Life Sciences Laboratory, Singapore

A germination interaction study of Clostridium novyi-NT spores reveals a novel non-canonical D-Amino acid germinant

12:15 - 12:20 PM Flash Talk - Dr. PJ Hensbergen, Leiden University Medical Center, the Netherlands

Novel insights in the structure and biosynthesis of the Clostridioides difficile flagellin C (FliC) Type A modification

12:20 – 12:30 PM Break

12:30 - 1:30 PM Poster Session ILive on Symposium (Asynchronous viewing possible)

Wednesday, September 15 (9 AM Boston, 3 PM Munich, 11 PM Melbourne)

Session IV: Session Chair - Dr. Chris Lopez, California State University, Sacramento

9:00 – 9:25 AM State-of-the-Art Lecture: Dr. Roman Melnyk (Toxins Sponsored Speaker), University of Toronto, Canada

Unraveling the role of intestinal bile acids in modulating C. difficile TcdB structure & function

9:25 - 9:50 AM Dr. Sabine Pellett, University of Wisconsin Madison, USA

Post-translational regulation of botulinum neurotoxin production in Clostridium botulinum Hall A-hyper

9:50 - 10:02 AM Short Talk - Dr. Christopher Peritore-Galve, Vanderbilt University, USA

Glucosyltransferase-independent effects of toxins A and B in the mouse model of C. difficile infection

10:03 - 10:15 AM Short Talk - Dr. Rongshen Jin, University of California, Irvine, USA

Structural basis for CSPG4 as a key receptor and therapeutic target for C. difficile toxin B

10:15 - 10:40 AM Dr. Brigitte Dorner, Robert Koch-Institut, Germany

Botulinum neurotoxins: New findings on receptor binding and how they translate into innovative detection approaches.

10:40 - 10:50 AM Break

Session V: Session Chair - Dr. Meera Unnikrishnan, Warwick University, United Kingdom

10:50 - 11:15 AM Dr. Julian Hurdle, Texas A&M University, USA.

How C. difficile evolves resistance to first-line drugs and its impact on patient care and global epidemiology.

11:15 – 11:40 AM Dr. Wiep Klaas Smits, Leiden University Medical Center

DNA replication in Clostridioides difficile, a potential target for antimicrobials

11:40 – 11:52 AM Short Talk - Dr. Jason Wilson, University of Sheffield, United Kingdom

CryoEM structure and structural characterisation of a Clostridioides difficile Myovirus phage

11:52 – 12:00 PM Short Talk - Dr. Horst Posthaus, University of Bern, Switzerland

News from the dark side (of the gut): Receptor specificity and function of Clostridium perfringens beta-toxin

12:05 – 12:10 PM Flash Talk - Anthony Pannullo, University of Iowa, USA

The Novel Two-Component System DraRS and its Role in Daptomycin Resistance in C. difficile

12:10 - 12:15 PM Flash Talk - Dr. Iman Mehdizadeh Gohari, University of Pittsburg, USA

Identifying the basis for VirS/VirR two-component regulatory system control of Clostridium perfringens beta toxin production

12:15 - 12:20 PM Flash Talk - Dr. Deiziane Viana da Silva Costa, University of Virginia, USA

Adenosine receptors differentially mediate enteric glial cell death induced by Clostridioides difficile toxins A and B

12:20 – 12:30 Break

12:30 - 1:30 PM Poster Session II – Live on Symposium (Asynchronous viewing possible)

Thursday, September 16 (9 AM Boston, 3 PM Germany, 11 PM Melbourne)

Session VI: Session Chair - Dr. Andrew Hryckowian, University of Wisconsin, Madison, USA

9:00 – 9:25 AM State-of-the-Art Lecture: Dr. Eric Skaar, Vanderbilt University Medical Center, USA.

Clostridioides difficile strategies to survive nutrient metal deprivation and excess.

9:25- 9:50 AM Dr. Lynn Bry, Brigham and Women’s Hospital, USA

Commensal control of C. difficile virulence.

9:50 - 10:02 AM Short Talk - Andrea Martinez Aguirre, University of Texas A&M, USA

Bile acid independent protection against C. difficile infection

10:03 - 10:15 AM Short Talk - Germán Vargas-Cuebas, Emory University School of Medicine, USA

Impact of glycine Stickland metabolism on Clostridioides difficile pathogenesis and its regulation in response to the host peptide LL-37

10:15 - 10:40 AM Dr. Nobuhiko Kamada, University of Michigan, USA

Microbe-metabolite-host interactions in the protection against Clostridioides difficile infection

10:40 - 10:50 AM Break

Session VII: Session Chair - Dr. Michael Abt, University of Pennsylvania, USA

10:50 - 11:15 AM Dr. Simon Hirota, University of Calgary, Canada

The interplay between neutrophils and innate lymphoid cells during TcdA/B-induced intestinal injury

11:15– 11:27 AM Short Talk - Dr. Zahidul Alam, University of Pennsylvania Perelman School of Medicine, USA

IL-10 producing regulatory T cells limits type 1 inflammation during persistent C. difficile infection and supports fecal microbiota transplantation engraftment

11:27 – 11:40 AM Short Talk - Dr. Esther Duperchy, Summit Therapeutics, United Kingdom

Metagenomic analysis of the impact of the precision antibiotic ridinilazole, compared to vancomycin, on the gut resistome in a Phase 2 study

11:40 – 12:05 PM Dr. Thomas Louie, University of Calgary School of Medicine, Canada

Fecal Microbiota Transplantation for recurrent CDI: Fine tuning and a paradigm shift improves safety and retains efficacy

12:05 – 12:15 PM Concluding Remarks

12:15 – 12:30 PM Break

12:30 – 2:00 PM Career Panel Discussion, Young Scientist's Meeting continued

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