Eclipsebio - Advanced RNA Genomics Solutions to Accelerate Your Research

Eclipsebio is a proud sponsor of the 7th annual Toronto RNA Enthusiasts Day (TREnD) 2022 Conference.

The Eclipse team is committed to supporting academia and industry in revolutionizing the emerging field of RNA genomics.

RNA research plays an integral role in vaccine development, basic biology discoveries, and medical breakthroughs. Eclipsebio makes comprehensive tools that reveal RNA structure, interactions and modifications on an unprecedented level.

By pairing our RNA genomics solutions with NGS technologies, we’re enabling researchers to make data-driven discoveries across the entire RNA landscape.

Building the world's most detailed multi-dimensional RNA maps

We offer both services and kits that provide more accurate, comprehensive and useable data for our customers, revealing detailed and novel insights into RNA biology.

Ribo-eCLIP

Reveal ribosome occupancy transcriptome-wide

Learn More About Ribo-eCLIP

Differential expression analysis

• Obtain differential expression analysis results between two samples from your RNA-Seq data and Ribo-eCLIP data
• Examine the ribosome occupancy differences (Ribo-eCLIP/RNA-Seq) between samples

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5' & 3' End-Seq

High Resolution Maps of the 5’ and 3’ UTR landscape

Learn More About End-Seq

Genome-Wide End Calling at Single Nucleotide Resolution

• Precise definition of transcription start sites and poly-adenylation sites at single nucleotide resolution
• End-Seq correctly identifies TSS and PAS for shorter isoforms expressed in the same sample with longer isoforms

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m6A-eCLIP

High Resolution Maps of the Epitranscriptome

Learn More About m6A-eCLIP

Unbiased m6A Modification Site Specificity

• Consistent with the known feature of m6A modifications, peaks of m6A-eCLIP reads are enriched near the stop codons, and for the 5 nt DRACH motif
• m6A-eCLIP shows similar read densities to a low-resolution m6A profiling technique m6A-RIP (meRIP), but with more precise site calls

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miR-eCLIP

High Resolution Maps of the miRNA-mRNA Interactome

Learn More About miR-eCLIP

Direct Detection of microRNA Targets

• miR-eCLIP utilizes a modified AGO2-eCLIP protocol to enhance ligation of miRNAs to target mRNAs yielding miRNA-mRNA chimeric fragments
• miR-eCLIP on human cells results in thousands of miRNA-mRNA chimeric reads that can be utilized for direct miRNA target identification

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Eclipsebio's RNA Genomics Solutions