Programme

Download the abstract booklet here.

All talks are in the Red Room, Donnelly Centre (160 College St)

* invited speaker

Monday, June 10

8:15am – 8:45am	Registration

Session 1: Hsp90 and systems biology (8:45am – 10:35am) – Chair: Walid A. Houry
8:45am – 9:00am	Opening remarks by organizers
9:00am – 9:20am	Leah Cowen (University of Toronto)*
	Global Proteomic Analyses Define an Environmentally Contingent Hsp90 Interactome and Reveal Chaperone-Dependent Regulation of Stress Granule Proteins and the R2TP Complex in a Fungal Pathogen
9:20am – 9:35am	Martin Duennwald (University of Western Ontario)
	Sti1 chaperones protein misfolding in ALS
9:35am – 9:50am	Rongmin Zhao (University of Toronto Scarborough)
	Role of molecular chaperone HSP90C in regulating PsbO1 homeostasis in the chloroplast stroma
9:50am – 10:05am	Leo Spyracopoulos (University of Alberta)
	Hsp90 - A perfect enzyme
10:05am – 10:20am	Georgios Karras (MD Anderson Cancer Center)
	Fantastic Protein-Folding Mutants and Where to Find Them
10:20am – 10:35am	Andrew Woolley (University of Toronto)
	A yeast system for discovering optogenetic inhibitors of eukaryotic translation initiation

10:35am – 11:00am	Coffee break

Session 2: Keynote speaker (11:00am – 12:00 pm) – Chair: Jason Young
11:00am – 12:00 pm	Jim Bardwell (University of Michigan and HHMI)*
	Chaperone-mediated folding

12:00pm – 1:30 pm	Group picture and lunch break

Session 3: Ubiquitin and proteostasis (1:30 pm – 2:50 pm) – Chair: Thibault Mayor
1:30 pm – 1:50 pm	Kalle Gehring (McGill University)*
	Regulation of mitochondrial quality control by parkin and PINK1
1:50 pm – 2:05 pm	Cordula Enenkel (University of Toronto)
	Proteasome Dynamics
2:05 pm – 2:20 pm	Wei Zhang (University of Guelph)
	Engineering protein-protein interactions to probe and rewire cell signaling
2:20 pm – 2:35 pm	El Bachir Affar (Maisonneuve-Rosemont Hospital Res Centre)
	Multiple layers of quality control regulatory mechanisms of the deubiquitinase BAP1
2:35 pm – 2:50 pm	Gil G. Prive (Princess Margaret Cancer Centre)
	BTB adaptors in E3 ligase complexes

2:50 pm – 3:10 pm	Coffee break

Session 4: Protein misfolding diseases 1 (3:10 pm – 4:30 pm) – Chair: Mikko Taipale
3:10 pm – 3:30 pm	Joel Watts (University of Toronto)*
	Strains of Pathological Protein Aggregates in the Synucleinopathies
3:30 pm – 3:45 pm	Neil Cashman (University of British Columbia)
	The pathological interactome of misfolded TDP-43 includes human wildtype SOD1
3:45 pm – 4:00 pm	Sue-Ann Mok (University of Alberta)
	Exploring the chaperone-tau interaction landscape during tau aggregation
4:00 pm – 4:15 pm	Timothy Audas (Simon Fraser University)
	Physiological Amyloid Aggregation: An Adaptive Response to Cellular Stress
4:15 pm – 4:30 pm	Patrick Lajoie (University of Western Ontario)
	The impact of expanded polyQ proteins on proteostasis: lessons from a yeast model of Huntington’s disease

4:40 pm – 5:30 pm	Panel discussion – future steps for PRinCE (4:40 pm – 5:30 pm)

6:00 pm – 8:30 pm	Cocktail reception and poster session (Stone Lobby, Medical Sciences Building)

8:30pm – late	Dinner and drinks at ~~Fran's Upper Deck~~ REDS, 382 Yonge St

Tuesday, June 11

Session 5: Chemical approaches (9:00 am – 10:25 am) – Chair: Jörg Gsponer
9:00 am – 9:20 am	David Vocadlo (Simon Fraser University)*
	Chemical biology methods to investigate the roles of O-GlcNAc in proteostasis
9:20 am – 9:35 am	Sharon Gorski (Michael Smith Genome Sciences Centre)
	A non-canonical role for caspases in the regulation of stress-induced autophagy.
9:35 am – 9:50 am	Ellen Vieux (C4 Therapeutics)
	Targeted Protein Degradation
9:50 am – 10:05 am	Gerold Schmitt-Ulms (University of Toronto)
	A mechanism-based small-molecule approach to the treatment of prion diseases that targets PrPC

10:05 am – 10:40 am	Coffee break

Session 6: Protein misfolding diseases 2 (10:40 am – 12:20 pm) – Chair: Jason Young
10:40 am – 11:00 am	Paul LaPointe (University of Alberta)*
	Disrupting proteostasis to enhance tumour immunogenicity
11:00 am – 11:15 am	Gergely Lukacs (McGill University)
	Mutations-specific contribution of peripheral protein quality controls to hERG channel loss-of-expression in LQT2 syndrome
11:15 am – 11:30 am	Sebastian Pechmann (Université de Montréal)
	Towards understanding protein homeostasis at a systems level through constraint-based whole-cell modeling
11:30 am – 11:45 pm	Mohan Babu (University of Regina)
	Deciphering the role of SACSIN in ARSACS
11:45 pm – 12:00 pm	Avi Chakrabartty (Princess Margaret Cancer Centre)
	Diagnosis and treatment of AL amyloidosis
12:00 pm - 12:20 pm	Christine Vande Velde (Universite de Montreal)*
	RNA binding proteins in Amyotrophic Lateral Sclerosis pathogenesis

12:20 pm – 2:00 pm	Lunch

Session 7: Stress response & Compartmentalization (2:00 pm – 4:00 pm) – Chair: Thibault Mayor
2:00 pm – 2:20 pm	Julie Forman-Kay (Hospital for Sick Children)*
	Phase separation of IDRs in RNA processing bodies
2:20 pm – 2:35 pm	P. H. St George-Hyslop (Univ of Cambridge & Univ of Toronto)
	Gel-like condensates of annexin 11 on lipid membranes enable RNP granule tethering to lysosomes
2:35 pm – 2:50 pm	Hyun Kate Lee (University of Toronto)
	Molecular chaperones modulate the dynamics of membrane-less organelles
2:50 am – 3:05 pm	Peter Stirling (Terry Fox Laboratory, BC Cancer Agency)
	Nuclear protein quality control during the DNA damage response in S. cerevisiae
3:05 pm – 3:20 pm	Janice Braun (University of Calgary)
	The Role of J Proteins in Extracellular Vesicles
3:20 pm – 3:35 pm	Marianne Koritzinsky (Princess Margaret Cancer Centre)
	Folding of secreted proteins in hypoxia

3:35 pm – 4:00 pm	Poster prizes and final comments

Registration period:

Submission period: