Program Overview

Saturday, November 9, 2019

12:00 – 1:30 pm Welcome Lunch

1:30 – 1:45 pm Opening Remarks (Alan Cohen, Tamàs Fülöp, Pierrette Gaudreau, and William Fraser)

1:45 – 3:00 pm Session 1: Comparative Biology of Aging

1:45 - 2:10 pm Jean-François Lemaitre

Sex differences in lifespan and ageing: what can we learn from comparative studies?

2:10 - 2:35 pm Anne Bronikowski

Insights into mechanisms of aging from comparative studies of reptiles

2:35 - 3:00 pm Vera Gorbunova

Mechanisms of longevity in long-lived mammals

3:00 – 3:30 pm Coffee Break

3:30 – 4:45 pm Session 2: Nutrition and Aging

3:30 - 3:55 pm José A. Morais

Leucine is not required in conjunction with resistance training and optimized protein intake to reverse frailty

3:55 - 4:20 pm Alistair Senior

Dietary Macronutrients, Age-Specific Mortality and Variation in Age at Death

4:20 - 4:45 pm Philipp Gut

Targeted Nutrition for Disease Management

4:45 – 6:00 pm Session 3: Mechanisms of Biological Aging

4:45 - 5:10 pm Jacek Witkowski

Proteodynamics and aging of cells and organisms

5:10 - 5:35 pm Pierrette Gaudreau

Metabolomic and lipidomic signatures of MetS in older adults of the NuAge cohort

5:35 - 6:00 pm Ganghui Liu

Programming and reprogramming of aging

6:00 – 7:00 pm Debate: Do we know what aging is?

Pro: Brian Kennedy

Con: Alan Cohen

7:00 – 8:00 pm Dinner/Cocktail (Z Tapas Lounge, Hotel Restaurant)

8:00 – 8:45 pm Keynote 1: Claudio Franceschi

Causes and implications of the heterogeneity of the aging phenotype

Sunday, November 10, 2019

7:30 – 8:15 am Breakfast (for hotel guests)

8:15 – 9:30 am Session 4: Aging, Frailty, and Complexity

8:15 - 8:40 am Andrea Maier

Determinants of recovery from acute disease at older age: the RESORT cohort

8:40 - 9:05 am Marcel G. M. Olde Rikkert

Getting Grip on Resilience in Aging Adults

9:05 - 9:30 am Arnold Mitnitski

Systems approach to aging and frailty

9:30 – 10:45 am Coffee Break and Posters

10:45 am – 12:00 pm Session 5: Big Data, Artiticial Intelligence, and Aging

10:45 - 11:10 am Quentin Vanhaelen

Transforming aging research and drug discovery with multimodal AI-based integrated approaches

11:10 - 11:35 am Serafim Rodrigues and Mathieu Desroches

Can Topology-Structure-Function relationship help understand ageing?

11:35 am - 12:00 pm Johannes Hertel

Frameworks of constructing metrics of biological age via data-driven procedures

12:00 – 12:50 pm Keynote 2: Luigi Ferrucci

Paving the road to new generation of studies of aging: the GESTALT study

12:50 – 2:00 pm Lunch

2:00 – 3:20 pm Session 6: Immunosenescence and Inflammaging

2:00 - 2:20 pm Graham Pawelec

Impact of immunosenescence on cancer immunotherapy

2:20 - 2:40 pm Julian Falutz

Aging with HIV: is it accelerated, accentuated, or just complicated?

2:40 - 3:00 pm Janko Nicolich-Zugich

Aging of lymph nodes sets a critical stage for age-related immune dysfunction

3:00 - 3:20 pm Daniela Frasca

Obesity and B cell immunosenescence

3:20 – 3:50 pm Coffee Break

3:50 – 5:05 pm Session 7: Cellular Senescence

3:50 - 4:15 pm Bertrand Friguet

Proteome oxidative modifications and impairment of metabolic pathways during cellular senescence and aging

4:15 - 4:40 pm Gerardo Ferbeyre

Senescence, aging and the nucleolus

4:40 - 5:05 pm Stathis Gonos

Proteasome activation delays aging and the progression of age-related diseases

5:05 – 6:35 pm Session 8: Geroscience

5:05 - 5:30 pm Brian Kennedy

Small molecule approaches to slow aging in humans

5:30 - 5:55 pm Vadim N. Gladyshev

From longevity signatures to longevity interventions

5:55 - 6:20 pm Alexey Moskalev

Transcriptomic changes in long-living strains of Drosophila melanogaster

6:20 - 6:35 pm Jeremy van Raamsdonk

Molecular pathways that contribute to longevity as novel therapeutic targets for neurodegenerative disease

7:00 pm Speaker dinner (Z Tapas Lounge, Hotel Restaurant)

Monday, November 11, 2019

7:30 – 8:15 am Breakfast (for hotel guests)

8:15 – 9:00 am Keynote 3: Dominique Gravel

Aging in multiple dimensions

9:00 – 10:15 am Session 9: Systems Biology of Aging

9:00 - 9:25 am Jackie Jing-dong Han

Heterogeneity of aging in human populations

9:25 - 9:50 am Steve Horvath

Comparative epigenetic aging studies in mammals

9:50 - 10:15 am Anatoliy Yashin

Genetic connection among aging, health, and longevity related traits: The results of recent analyses

10:15 – 10:45 am Coffee Break

10:45 am – 12:00 pm Session 10: Age-Related Diseases

10:45 - 11:10 am Andrei Seluanov

The role of transposable elements in inflammaging

11:10 - 11:35 am Andreas Simm

Advanced Glycation Endproducts and Nutrition: Friend or foe during aging?

11:35 am - 12:00 pm André Carpentier

Adipose tissue metabolic dysfunction in cardiometabolic diseases

12:00 – 1:00 pm Lunch

1:00 – 2:15 pm Session 11: Longitudinal Studies

1:00 - 1:25 pm Parminder Raina

Integrating population aging and biology using CLSA as a platform

1:25 - 1:50 pm Joris Deelen

The genetic and metabolomic signatures of human longevity and lifespan

1:50 - 2:15 pm Anis Larbi

T cell aging in aging

2:15 – 2:45 pm Coffee Break

2:45 – 4:00 pm Session 12: Complexity and Aging

2:45 - 3:10 pm Svetlana Ukraintseva

Mechanisms of the decline in resilience during aging: Role of genes regulating cell responses to damage

3:10 - 3:35 pm Adam Freund

Untangling Aging Using Dynamic, Organism-Level Phenotypic Networks

3:35 - 4:00 pm Janet Thornton

Computational approaches to unravel the complexities of Ageing and repurpose drugs for geroprotection

4:00 – 5:15 pm Session 13: Interventions

4:00 - 4:25 pm Stephen Cunnane

Brain energy rescue with ketones in Alzheimer’s disease: progress with clinical trials

4:25 - 4:50 pm Katsuiku Hirokawa

Immune status of cancer patients and the effect of DC therapy with WT-1 peptide on immunity and prognosis

4:50 - 5:15 pm Jing Qu

Gene therapy alleviates osteoarthritis by preventing stem cell senescence

5:15 – 5:30 pm Closing Remarks