GPCR RETREAT 2025

PROGRAM

THURSDAY MAY 15th

Room check-in: 16:00. Luggage storage rom: Dunham.

REGISTRATION

11:00 Arrival and registration

13:00 Welcome Remarks (Room: Bromont ABC)

TRAINEE SYMPOSIUM (Sponsored by American Society for Pharmacology and Experimental Therapeutics (ASPET) and Fond d’Appui à l’Engagement Etudiant (FAEE)

Chairs: Laurie Arpin, Tarek Benchaar, Isabelle Bérubé and Laurie Côté, Université de Sherbrooke

13:15 Kaden Baskerville, University of Manitoba, Canada. ^"Novel trans-cellular interaction between neurexin-1 and mGluR5"

13:30 Ana Lilia Moreno Salinas, Université de Sherbrooke, Canada. "Comprehensive characterization of ADGRE5/CD97 signaling: Insights into Protelolytic and Mechanical Activation"

13:45 Brianna Vonderhaar, University of Rochester, USA. "Orphan G protein coupled receptor GPR156 functional interactome studies".

14:00 Camila Kiyan, IRIC - University of Montreal, Canada. "Mechanistic insights into GPCR-triggered ERM activation: Essential roles of Gaq, Ga12/13, Rho and Kinases SLK/LOK".

14:15. Xiaohan Zhou, University of Toronto, Canada. "Investigating the basal signaling dynamics of GPCRs using single-molecule fluorescence".

14:30. Simon Hasinger, Medical University of Vienna, Austria. "Exploring evolutionary conserved neuropeptide systems in invertebrates for drug discovery".

14:45. Teophile Lemay, McGill University, Canada. "Quantifying GPCR-G protein binding affinity via a steady-state fluorescence fluctuations with two-color image cumulant analysis".

15:00 Sandra Gostynska, University of Oklahoma Health Sciences Center, USA. "Amylin receptor subunit interactions are modulated by agonists and determine signaling".

15;15 Coffee Break

16:00 ASPET - Awards for Student Oral Presentations

MARC G. CARON KEYNOTE LECTURES (Sponsored by Dr Kathleen Caron and Family)

Chair: Martin Beaulieu, University of Toronto

16:30 Mark Von Zastrow, University of California, San Francisco, CA, USA. "Exploring the inner life of GPCRs"

17:00 Jeffrey L Benovic, Thomas Jefferson University, Philadelphia, PA, USA. "Biasing β2-adrenergic receptor signaling".

17:30. Welcome reception and poster session #1 (odd numbers) - Room: Salons Knowlton & Nouvelle Angleterre

19:30 Dinner - Room: Bromont ABC

FRIDAY MAY 16th

6:30-8:30 Breakfast - Room: Les Quatre Canards

SESSION 1: STRUCTURAL AND DYNAMIC ASPECTS OF GPCRs

Chairs: Martin Audet and Louis-Philippe Picard, Université de Sherbrooke.

8:30 Georgios Skiniotis, St-Jude Research, Memphis, TN, USA. "Non-Equilibrium Structural Pharmacology of the μ-Opioid Receptor."

8:55 Andrew Kruse, Harvard, MA, USA. ^"Structural insights into G protein-coupled receptor signaling".

9:20 Daniel Wacker, Mount Sinai, NYC, USA. "Structural determinants of G protein subtype selectivity at a the serotonin receptor".

9:45 Cornelius Gati, University of Southern California, USA."Molecular mechanisms of inverse agonism via κ-opioid receptor-G protein complexes".

10:10 Coffee Break

SESSION 2: GPCR SIGNALING AND TRAFFICKING I

Chair: Stéphane Laporte, McGill University.

10:30 Roshanak Irannejad, University of California, San Francisco, CA, USA. "Monoamine Transporters: The Dynamic Modulators of Subcellular GPCR Activity".

10:55 Manojkumar Puthenveedu, University of Michigan Medical School, MI, USA. "Location bias as the primary mode for pH-sensing through GPR65".

11:20 Bianca Plouffe, Queen’s university Belfast, UK. "From endosomal Gq signalling to cellular response: what happens between?"

11:45 Michel Bouvier, Université de Montréal, Canada. "Pharmacological Chaperones for the Treatment of GPCR Misfolding Diseases".

12:10 Lunch (Room : Les Quatre Canards)

SESSION 3: GPCR SIGNALING AND TRAFFICKING II

Chair: Elie Besserer-Offroy, Université de Caen-Normandie and Andy Chevigné, Luxembourg Institute of Health.

14:00 Mikel Garcia-Marcos, Boston University, Boston, MA, USA. "The Secret Life of G proteins".

14:25 Gregory Tall, University of Michigan School of Medicine, MI, USA. "The adhesion GPCR tethered agonist mechanism and the design and use of adhesion GPCR ectodomain / Fc fusion proteins for deorphanization efforts".

14:50 Shane Wright, Karolinska Institutet, Sweden. "Beyond G protein and β-arrestin biased agonism".

15:15 Coffee Break

SESSION 4: Hubert van Tol session on PHYSIOLOGY, NEUROSCIENCE AND MODEL ORGANISMS (Sponsored by Dr Monica Seger and Family).

Chairs; Mario Tibéri, University of Ottawa and Henry A. Dunn, University of Manitoba.

15:30 Mannix Auger-Messier, Université de Sherbrooke, Canada. "Turning up the beat with tunable Angiotensin II type 1 receptor analogs".

15:55 Stéphane Angers, University of Toronto, Canada. "A New Lens on Wnt Receptor Activation Drives a First-in-Class Therapy for Retinal Diseases".

16:20 Stephanie Borgland, University of Calgary, Canada. "How Orexin and Dynorphin Rewire the Brain’s Reward Circuit After Morphine".

16:45 Paul Albert, University of Ottawa, Canada. "Biased 5-HT1A receptor agonists reorganize serotonin projections for rapid antidepressant action."

17:15 Poster session #2 (even numbered posters) - Room: Salons Knowlton & Nouvelle Angleterre

19:30 Dinner and Music (Room: Bromont ABC)

21:30. DJ and Dance (Room: Bromont ABC)

SATURDAY MAY 17th

Room check-out: 11:00. Luggage storage room: Dunham

6:30-8:30 Breakfast (Room : Les Quatre Canards)

7:30-8:30 Breakfast for Board Meeting (to discuss next retreat, Open to all PIs) - Room: Les Cantons

SESSION 5: DRUG DISCOVERY

Chairs: Philippe Sarret and Pierre-Luc Boudreault, Université de Sherbrooke.

8:30 Brian K. Shoichet, University of California, San Francisco, USA. "Directed and Random Walks in Chemical Space".

8:55 Terence Hébert, McGill University, Canada. "Combining induced pluripotent stem cells and biosensors for GPCR-based drug discovery".

9:20 Christian Gruber, Medical University of Vienna, Austria. "Peptide-based approaches to GPCR drug discovery: design of novel κ-opioid receptor ligands with distinct signaling profiles".

9:45 Laurent Sabbagh, Domain Therapeutics NA, Inc, Canada. "Therapeutic potential of a novel PAR2 inhibitor with best-in-class properties in immuno-oncology and inflammatory disorders".

10:10 Coffee break

SESSION 6: NON-CONVENTIONAL ASPECTS of GPCRs

Chair: Laurent Sabbagh, Domain Therapeutics North America.

10:30 Tobias Langenhan, Leipzig University, Germany. "How to transduce force into biochemical commands - Mechanosensing by adhesion GPCRs".

10:55 Demet Arac, University of Chicago, USA. "Structure, Dynamics and Activation of a Holo Adhesion GPCR: An Extracellular Region-Dependent Mechanism".

11:20 Reika Tei, Standford University, USA. "Synthetic GPCRs for programmable sensing and control of cell behavior".

HYMAN NIZNIK PLENARY CONFERENCE

Chair: Michel Bouvier, Université de Montréal

11:45 M Madan Babu, St-Jude Research, Memphis, TN, USA. "Data Science approaches to GPCR signaling and implications for drug discovery".

12:30 Closing remarks

12:45 Lunch and Farewell (Room : Les Quatre Canards)