Adhere2 Programme

Wednesday 3/9/2025

15:00-18:00 Registration & Poster Assembly

18:00-18:15 Opening remarks

18:15-19:15 The Keynote Lecture

Johanna Ivaska: “Integrin mediated cell adhesion in modulation of cancer progression”

19:15- Welcome reception

Thursday 4/9/2025

8:30 Registration desk opens

9:00-10:40 Session 1 - Cell adhesions 1

Chairs: David Calderwood & Ben Goult

9:00-9:25 Bernhard Wehrle-Haller: “Regulation of fibronectin fiber assembly by post-translational modification of beta1-integrins”

9:25-9:50 Christoph Ballestrem: “How the cellular environment modulates tensin3 to undergo liquid-liquid phase separation”

9:50-10:15 Haguy Wolfenson: “Enzymatic regulation of fibronectin fibrillogenesis: a novel route for fibrosis inhibition

10:15-10:40 Nikolina Stojanović: "The role of talin2-KANK2 functional interaction in focal and fibrillar adhesions”

10:40-11:45 Coffee break^#

11:45-13:00 Session 2 - Cell adhesions 2

Chairs: Reinhard Fässler & Andreja Ambriović-Ristov

11:45-12:10 David Calderwood: “Organization and dynamics of focal adhesion proteins”

12:10-12:35 Staffan Strömblad: “Mechanical regulation of hemidesmosomes”

12:35-13:00 Jim Norman: “Unexpected roles of the mRNA translation machinery in influencing α5β1-integrin function to generate fibronectin-rich tumour initiation niches in the liver”

13:00-15:00 Lunch

15:00-16:40 Session 3 - Mechanobiology

Chairs: Staffan Strömblad & Vassiliki Kostourou

15:00-15:25 Miguel Angel del Pozo: “Tension-sensing membrane domains in mechanoadaption and mechanotransduction”

15:25-15:50 Adam Byron: “Mechano-regulation of gene expression by adhesion proteins”

15:50-16:15 Sangyoon Han: "Feedback interaction between FAK and talin mechanosensitivity for stiffness sensing"

16:15-16:40 Ben Goult: “Mechanical control of enzymatic processes via talin

16:40-17:45 Coffee break^#

17:45-18:15 Session 4 - Extracellular matrix and vesicles

Chairs: Maddy Parsons & Matt Jones

17:45-18:10 Reet Kurg: “Unraveling the origin of extracellular vesicles”

18:10-18:35 Smadar Ben Tabou de Leon: “The mechano-genetic regulation of biomineralization in the sea urchin embryo”

19:00-20:00 Dinner

20:00-22:30 Poster session with cheese and wine

Friday 5/9/2025

8:30 Registration desk opens

9:00-10:40 Session 5 - Adhesion Signalling 1

Chairs: Miguel Angel del Pozo & Jim Norman

9:00-9:25 Reinhard Fässler: “to be announced”

9:25-9:50 Corinne Albiges-Rizo: “Decoding cell migratory strategies”

9:50-10:15 Susanna C Fagerholm: “Integrins as regulators of dendritic cell mechanical immune memory"

10:15-10:40 Olivier Rossier: "Defining how the shape of talin supports its function inside living cells"

10:40-11:45 Coffee break^#

11:45-13:00 Session 6 - Adhesion in Cancer

Chairs: Ivan De Curtis & Susanna C Fagerholm

11:45-12:10 Mark Morgan: “Integrin-RTK crosstalk in cancer and fibrosis”

12:10-12:35 Patrick Caswell: “Matrix assembly in the ovarian cancer metastatic niche”

12:35-13:00 Tobias Zech: “Mechanical regulation of metabolism to fuel cancer progression”

13:00-14:00 Lunch

14:30-22:30 Boat trip with dinner

Saturday 6/9/2025

8:30 Registration desk opens

9:00-10:15 Session 7 - Cell adhesions and disease

Chairs: Bernhard Wehrle-Halle & Sangyoon Han

9:00-9:25 Maddy Parsons: “Epithelial adhesion receptors in tissue inflammation”

9:25-9:50 Mirjana Liović: “The effect of the amount of mutant keratin protein expressed on the EB simplex adhesome”

9:50-10:15 - Vesa Hytönen: "Talin is associated with multiple diseases"

10:15-10:40 Coffee break

10:40-12:30 Session 8 - Adhesion Signalling 2

Chairs: Arnoud Sonnenberg & Christoph Ballestrem

10:40-11:05 Alexander D Bershadsky: “Integrin-based Adhesion Modules in a Crosstalk with Microtubules”

11:05-11:40 Ivan de Curtis: “Assembly and regulation of plasma membrane-associated networks at the front of motile cells”

11:40-12:05 Thomas Zacharchenko: "Structural analysis of adhesion protein interactions"

12:05-12:30 Paul Atherton: "The regulation of Liprin-α clustering by ECM cues"

12:30-12:50 Poster prize and Closing remarks

13:00-15:00 Lunch & Departure

#Coffee breaks will take place adjacent to the poster area to allow more discussion time.