Schedule

Cláudia Mendes (ASAP Project Manager) will welcome participants and describe how to join a poster discussion during this event.

The neuromodulator networks interacting with dopamine axons are in a powerful position to rescue or exacerbate dopamine dysfunction in Parkinson’s disease (PD) yet are surprisingly poorly understood. This session will detail state-of-the-art tools and models used by our ASAP team to define the neuromodulators, cells and circuits, neuronal and non-neuronal, that act on and through axons of vulnerable dopamine neurons.

Accurately modeling a disease is essential to understanding its etiology, and many different mice PD models exist in the research community. This session will highlight recent findings in behaving mice from our ASAP team that uncover the extents to which dopamine and neuromodulator partner dynamics become imbalanced across vulnerable and resistant striatal territories during progression of PD and the emergence of motor symptoms.