Notez que toutes les conférences auront lieu dans les auditoriums S1-151 & S1-111 du Pavillon Jean-Coutu | Campus de l’Université de Montréal.

Please note that all presentations will take place in the auditoriums S1-151 & S1-111 - Jean-Coutu Pavilion | Université de Montréal campus.

PROGRAMME | PROGRAM

DIMANCHE 2 JUIN | SUNDAY JUNE 2, 2019

12:00 - Accueil des participants | Welcome of participants

13:00 - 14:20                    Atelier I - Équité, diversité et inclusion – Salle S1-151|
                                        Workshop I - Equity, Diversity and Inclusion – Room S1-151
                                        Modératrice | Moderator: Katherine Borden [IRIC, Université de Montréal]

                                        Ève Langelier [Université de Sherbrooke], Chaire pour les femmes en sciences et en génie au Québec |
                                     Chair for Women in Science and Engineering in Quebec
                                        Imogen Coe [Ryerson University]
                                        Michael Hendricks [McGill University]
                                        Roxane de la Sablonnière [Université de Montréal]

14:20 - 15:50                    Atelier II - Science & société – Salle S1-151|
                                        Workshop II - Science & Society – Room S1-151
                                        Modérateur | Moderator: Tarik Möröy [Institut de recherches cliniques de Montréal]

                                        Mona Nemer, Conseillère scientifique en chef du Canada | Chief Science Advisor of Canada
                                        Marie Franquin, Co-présidente | Co-President, Science & Policy Exchange
                                        Éric Racine [Institut de recherches cliniques de Montréal]

15:50 - 16:00 Pause | Break

16:00 - 16:10 Mot de bienvenue – Salle S1-151 | Welcome address – Room S1-151
Tarik Möröy, Président de la SCBM | CSMB President

16:10 - 17:30 Présentations par des récipiendaires de prix – Salle S1-151 |
Talks by Awardees – Room S1-151

                                        Jonathan Schertzer [McMaster University], récipiendaire du prix "Nouveau scientifique" | "New Investigator" Awardee
                                        Glucose symbiosis between microbiota and host
                                        Anne-Claude Gingras [LTRI, University of Toronto], récipiendaire du prix "Conférence d'honneur Jeanne Manery Fisher" |                                      "Jeanne Manery Fisher Memorial Lecture" Awardee
                                        A proximity map of a human cell

17:30 - 17:45 Pause | Break

17:45 - 18:45                    Conférence d’ouverture – Salle S1-151 | Keynote Lecture – Room S1-151
                                        Helen McNeill [Washington University in St. Louis]
                                        Coordinating tissue growth and organization

18:45 - 21:00 Cocktail de réseautage | Networking Cocktail

LUNDI 3 JUIN 2019 | MONDAY JUNE 3, 2019

Session I – A: Levures I – Salle S1-111| Yeast I – Room S1-111
Modérateur | Moderator: Hugo Wurtele

8:30 - 10:15                      Jennifer Cobb [University of Calgary]
                                        Dyskerin in yeast contributes to checkpoint activation and DNA repair at a DSB
                                        Phil Hieter [University of British Columbia]
                                        Setting a trap for cancer cells: Screening with catalytically inactive mutations to discover new synthetic lethality-based                                         therapeutic targets
                                        Kin Chan [University of Ottawa]
                                        The pattern of mutations induced by metabolic processes in yeast closely resembles mutational signature 5 in cancers
                                        Larasati [University of Waterloo]
                                        Characterization of the Rif1-Dbf4 interaction in Saccharomyces cerevisiae
                                        Rodrigo Reyes [McGill University]
                                        Subunit dynamics in the eukaryotic replisome in live cells

Session I – B: Modèles biochimiques et biophysiques – Salle S1-151| Biochemical & Biophysical Models – Room S1-151

Modératrice | Moderator: Katherine Borden

8:30 - 10:15                     Yuh Min Chook [University of Texas Southwestern Medical Center]
                                      Karyopherins as chaperones
                                        Julie Forman-Kay [Hospital for Sick Children, University of Toronto]
                                        Phase separation biophysics and implications for biological function
                                        Kalle Gehring [McGill University]
                                        Cysteine phosphorylation in the PRL/CNNM pathway and cancer
                                        Mohammadjavad Paydar [IRIC, Université de Montréal]
                                        Ternary complex of two bent tubulin heterodimers held head-to-tail by AMP-PNP-bound Kif2A provides molecular insight into                                         the action of Kinesin-13 at microtubule ends
                                        Swati Singh [IRIC, Université de Montréal]
                                        Evolved plasticity of RAS family GTPase interactions with effector binding domains

10:15 - 10:45 Pause Café | Coffee Break

Session II –A: Invertébrés I – Salle S1-151| Invertebrates I – Room S1-151

Modératrice | Moderator: Esther Verheyen

10:45 - 12:30                    Julie Claycomb [University of Toronto]
                                        Understanding small RNA-mediated gene regulation through the lens of C. elegans Argonautes
                                        Abigail Gerhold [McGill University]
                                        Mitosis in situ – how context shapes cell division
                                        Ian Chin-Sang [Queen’s University]
                                        Identification of novel regulators of Insulin-like signaling and characterization of the 40 Insulin-like peptides in C. elegans
                                        Damien Garrido [IRIC, Université de Montréal]
                                        The role of Cyclin B3 in anaphase onset in Drosophila
                                        Eugénie Goupil [IRIC, Université de Montréal]
                                        Elucidating the role of OSGN-1 in Rho signalling in C. elegans

Session II –B: Levures II – Salle S1-111 | Yeast II – Room S1-111

Modératrice | Moderator: Lea Harrington

10:45 - 12:30                    Sveta Makovets [University of Edinburgh]
                                        Using budding yeast to understand the population dynamics in cells with telomerase insufficiency
                                        Hugo Wurtele [HMR, Université de Montréal]
                                        Sirtuin-mediated histone deacetylation promotes DNA replication in cells with short telomeres
                                        Michael Downey [University of Ottawa]
                                        Polyphosphorylation as a new lysine PTM
                                        Elizabeth Walden [University of Ottawa]
                                        Phenomic screen implicates the yeast lysine acetyltransferase NuA4 in regulation of glycogen synthesis and mitochondrial                                         morphology through the PKA inhibitor Bcy1
                                        Vy Ngo [Western University]
                                        Novel crosstalk between the antioxidant and heat shock responses in cancer

12:30 - 14:00 Dîner | Lunch

14:00 - 16:00 Session présentations par affiches | Poster Session

Session III –A: Modèles murins I – Salle S1-151| Murine Models I – Room S1-151

Modératrice | Moderator: Anastasia Nijnik

16:00 - 17:45                    Anastasia Nijnik [McGill University]
                                        MYSM1 Maintains Ribosomal Protein Gene Expression in Hematopoietic Stem Cells: Implications for the Human                                         MYSM1-Deficiency Syndrome
                                        Pierre Priam [IRIC, Université de Montréal]
                                        SMARCD1 subunit of SWI/SNF complexes collaborates with E2A to promote lymphoid specification
                                        Katie Teng [McGill University]
                                        Modeling High-grade serous ovarian carcinoma using in vivo oviduct electroporation, CRISPR/Cas9-mediated genome editing                                         and lineage tracing
                                        Chidalu Edechi [University of Manitoba]
                                        PIP overexpression in 4T1 cells slows down breast cancer progression in a transplantable mouse model
                                        Jennifer Fraszczak [Institut de recherches cliniques de Montréal]
                                        GFI1/LSD1 complex is required to control inflammation in a specific monocyte population

Session III –B: Biologie chimique – Salle S1-111| Chemical Biology – Room S1-111

Modératrice | Moderator: Julie Forman-Kay

16:00 - 17:45                    Joelle Pelletier [Université de Montréal]
                                        Creating and exploiting drug resistance in classical DHFRs and inhibiting new ones
                                        Ann English [Concordia University]
                                        Live-cell FLIM imaging of protein heme loading: the extraordinary case of cytochrome c peroxidase
                                        FuiBoon Kai [University of California, San Francisco]
                                        Extracellular matrix dimensionality reduces cellular cortical tension to stimulate Arf6/Rac pro-survival signaling in mammary                                         epithelial cells
                                        Dalia Barsyte-Lovejoy [University of Toronto]
                                        Chemical biology in epigenetics: from chemical tools in cancer models to clinical applications
                                        Doris Schuetz [IRIC, Université de Montréal]
                                        Integrating interaction hotspots of the SOS/Ras complex to rationalize small molecule design

MARDI 4 JUIN 2019 | TUESDAY JUNE 4, 2019

Session IV –A: Modèles dérivés de patients – Salle S1-151 | Patient-derived Models – Room S1-151

Modératrice | Moderator: Kristin Hope

8:30 - 10:15                      Ming-Sound Tsao [University of Toronto]
                                      New patient-derived models to study human lung cancer
                                        Jennifer Chan [University of Calgary]
                                        The role of CIC loss and ETS de-repression in gliomagenesis
                                        Thomas Milan [IRIC, Université de Montréal]
                                        Integrative epigenomic analysis to identify potential biomarkers in KMT2A translocated acute myeloid leukemia
                                        Elena Kuzmin [McGill University]
                                        Evolution of large copy number variants in breast cancer through genetic network rewiring
                                        Veronique Lisi [CUSM/ LDI]
                                        Single cell analysis of oncohistone mutation effect on transcriptional program in pediatric high-grade gliomas

Session IV –B: Modèles murins II – Salle S1-111| Murine Models II – Room S1-111

Modérateur | Moderator: Jean-François Côté

8:30 - 10:15                     Josie Ursini-Siegel [LDI, McGill University]
                                      Novel therapeutic strategies to increase the clinical impact of biguanides in oncology
                                        Daniel Schramek [LTRI, University of Toronto]
                                        In vivo veritas – using CRISPR to unearth novel cancer genes
                                        Paola Marignani [Dalhousie University]
                                        Using CRISPR-Cas9 mouse model to study lung cancer
                                        Marjorie Lapouge [IRIC, Université de Montréal]
                                        Myc as a downstream effector of Yes in hepatocarcinogenesis
                                        Adam Golding [University of Guelph]
                                        Investigating the role of Nck cytoskeletal adaptors in mammary development and breast cancer

10:15 - 10:45 Pause Café | Coffee Break

Session V –A: Modèles d'hématopoïèse et d'immunité contre le cancer – Salle S1-111|
Models of Hematopoïesis and Cancer Immunity – Room S1-111

Modérateur | Moderator: André Veillette

10:45 - 12:30                    André Veillette [Institut de recherches cliniques de Montréal]
                                        SLAM family receptors in immune cells
                                        Kevin Bennewith [BC Cancer Agency Research Centre]
                                        Regulatory T cells in the lung microenvironment: implications for tumour growth in the lungs
                                        Yeji An [Hospital for Sick Children]
                                        Cdh1 and Pik3ca mutations cooperate to induce Immune-Related Invasive Lobular Carcinoma of the breast
                                        Julie Ross [Institut de recherches cliniques de Montréal]
                                        Deletion of the Miz-1 POZ domain increases efficacy of cytarabine treatment in T- and B-ALL/lymphoma mouse models
                                        Morla Phan [University of Guelph]
                                        Effect of Rapamycin on Canine Mast Cell Cancer Cell DNA Damage Responses Following Radiation

Session V –B: Modèles cellulaires et tissulaires – Room S1-151 | Cellular and Tissues Models – Room S1-151

Modérateur | Moderator: François Boudreau

10:45 - 12:30                    François Boudreau [Université de Sherbrooke]
                                        A central role for the nuclear receptor HNF4alpha in the regulation of intestinal homeostasis
                                        Marjorie Brand [OHRI, University of Ottawa]
                                        Understanding cell fate decisions in erythropoiesis using quantitative proteomics and single-cell mass cytometry
                                        Lisa Julian [Ottawa Hospital Research Institute]
                                        A Multi-system Stem Cell Model of Tuberous Sclerosis Neoplasms Reveals Lineage-specific Proteostasis Signaling and                                         Therapeutic Sensitivities
                                        Léo Aubert [IRIC, Université de Montréal]
                                        A surfaceome-based CRISPR/Cas9 screen reveals unexpected vulnerabilities in KRAS-addicted colorectal cancers
                                        John Abousawan [Ryerson University]
                                        A switch in EGFR nanoscale organization upon HER2 co-expression defines unique signaling in breast cancer cells

12:30 - 14:00 Dîner | Lunch

14:00 - 15:30 Assemblée générale SCBM – Salle S1-111 | CSMB General Assembly – Room S1-111

Atelier III - planification carrière – Salle S1-151 | Workshop III - Career Planning – Room S1-151
Modératrice | Moderator: Marianne Chevrier

Claude Perreault, Professeur titulaire |Full Professor, IRIC - Université de Montréal
Stephanie Weber, Professeure adjointe |Assistant Professor, McGill University

                                        Michel Paré, Gestionnaire senior d’agents de liaison médicale, Novo Nordisk| Senior Manager MSLs, Novo Nordisk
                                        Julie Lambert, Conseillère principale aux relations gouvernementales et institutionnelles | Senior Advisor, Government and                                         Institutional Relations, Université de Montréal
                                        Martin Primeau, Journaliste/ recherchiste/ créateur de contenu/ rédacteur indépendant | Journalist/ Researcher/ Content                                         Creator/ Editor

Session VI –A: Invertébrés II – Salle S1-151| Invertebrates II – Room S1-151

Modérateur | Moderator: Jean-Claude Labbé

15:30 - 17:15                    Bob Goldstein [University of North Carolina at Chapel Hill]
                                        Tardigrades: an emerging model system for studying how life can survive extremes
                                      Julie Brill [Hospital for Sick Children]
                                        Nuclear and perinuclear PIP2 signaling – lessons from Drosophila
                                        Caroline Baril [IRIC, Université de Montréal]
                                        A genetic screen in Drosophila uncovers functional modulators of the NUP98-HOXA9 human oncoprotein
                                        Kimberley Gauthier [McGill University]
                                        LIN-2/7/10 complex revisited: complex-independent function of LIN-10 (APBA) and LIN-7 (Veli) in EGFR signaling in C. elegans
                                        Virginie Mondin [IRIC, Université de Montréal]
                                        A PTEN/PLC pathway reduces endosomal PI(4,5)P2 and can compensate for loss of the OCRL phosphatase

Session VI –B: Modélisation par ordinateur – Salle S1-111 | Computational Modelling – Room S1-111

Modérateur | Moderator: Michelle Scott

15:30 - 17:15                    Sébastien Lemieux [IRIC, Université de Montréal]
                                         A neural network-based approach to dimensionality reduction with applications in transcriptomics
                                        Quaid Morris [University of Toronto]
                                        Reading the fossil record of a cancer
                                        Guillaume Poirier-Morency [IRIC, Université de Montréal]
                                        miRBooking 2.0: an Enzymatic Model for the Microtargetome
                                        Hoang Dong Nguyen [Université de Sherbrooke]
                                        Search for new biomarkers related to human brain IDH-wt cancer
                                        Thierry Bertomeu [IRIC, Université de Montréal]
                                         Parallelized genome-wide CRISPR screens uncover chemical mechanism-of-action and gene function

18:00                                 Souper | Dinner
                                         1909 Taverne Moderne
                                      1280 Avenue des Canadiens-de-Montréal
                                         Montréal, QC H3C 5L2

Métro Lucien-L’Allier Metro Station

MERCREDI 5 JUIN 2019 | WEDNESDAY JUNE 5, 2019

Session VII –A: Invertébrés III – Salle S1-111 | Invertebrates III – Room S1-111

Modératrice | Moderator: Abigail Gerhold

8:30 - 10:15                      Esther Verheyen [Simon Fraser University]
                                        Decoding nutrient sensing and metabolic rewiring in the Hipk tumor model
                                        Patrick Laprise [CRCHU, Université Laval]
                                        Drosophila melanogaster as a model system to unravel the link between loss of epithelial cell polarity and cancer progression
                                      Amel Chaouch [McGill University]
                                        Expression of human oncogenic mutant histone H3.3 in Drosophila melanogaster disrupts development and compromises                                         tissue-specific transcriptional regulation
                                        Cédric Plutoni [IRIC, Université de Montréal]
                                        Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration
                                        Silvana Jananji [IRIC, Université de Montréal]
                                        Insights into the function of the scaffold, Anillin, from the analysis of ectopic nuclear filaments

Session VII –B: Modèles vertébrés – Room S1-151 | Vertebrate Models – Room S1-151

Modérateur | Moderator: Vincent Archambault

8:30 - 10:15                      Vera Gorbunova [University of Rochester]
                                        Anticancer mechanisms in long-lived mammals
                                        Peng Huang [University of Calgary]
                                        Maintenance of tissue integrity by fibroblasts originated from the sclerotome
                                        Stéphane Roy [Université de Montréal]
                                        Tissue regeneration in the axolotl (A New Era for an Old model)
                                        Rana Amini [Max Planck Institute of Molecular Cell biology and Genetics]
                                        Investigating cell and tissue organising principles of horizontal cell lamination in the vertebrate retina
                                        Pierre Couvineau [IRIC, Université de Montréal]
                                        Monitoring Signalling and trafficking of Neurotensin Type 1 Receptor in Animal Model using fluorescent-based methods

10:15 - 10:45 Pause Café | Coffee Break

10:30 - 12:30 Session présentations par affiches | Poster Session

12:30 - 14:00 Dîner | Lunch

Session VIII –A: Cellules souches – Salle S1-151 | Stem Cells – Room S1-151

Modératrice | Moderator: Julie Lessard

14:00 - 15:45                    Michel Cayouette [Institut de recherches cliniques de Montréal]
                                      Regulating cell numbers in the developing nervous system
                                        Kristin Hope [McMaster University]
                                        Uncovering post-transcriptional circuitries underlying hematopoietic stem cell function
                                        Bill Stanford [Ottawa Hospital Research Institute]
                                        Stem cell models identify proteasome inhibition as a potential therapy for tuberous sclerosis neural but not mesenchymal                                         tumors
                                        Bernhard Lehnertz [IRIC, Université de Montréal]
                                        A Genetically Encoded Human Hematopoietic Stem Cell (HSC) Reporter
                                        Mathieu Tremblay [McGill University]
                                        A GATA3/BMP axis regulates normal and cancerous prostate stemness

Session VIII –B: Biologie synthétique et ingénierie génomique – Salle S1-111 |
Synthetic Biology and Genome Engineering – Room S1-111

Modérateur | Moderator: Malcolm Whiteway

14:00 - 15:45                    Hans-Joachim Wieden [University of Lethbridge]
                                        From sequence to function and back again - Structural dynamics as a designable feature and its application in precision health
                                      Laura Simon [IRIC, Université de Montréal]
                                        Whole-genome CRISPR-Cas9 screen of the glucocorticoid response in AML identifies PLZF as an important driver of                                         resistance
                                        Samuel Jacques [IRIC, Université de Montréal]
                                        A synthetic biology platform to generate and screen natural product-like chemical matter
                                        Uri David Akavia [McGill University]
                                        Monoavidin Engineered CRISPR proteins allow increased rate of Homology Directed Repair and receptor-mediated specificity
                                        Sophie Cardin [CHU Sainte-Justine]
                                        Synthetic human models of NUP98-KDM5A acute megakaryoblastic leukemia reveal novel disease biomarkers

15:45 - 16:00 Pause | Break

16:00 - 17:00 Présentations par des récipiendaires de prix – Salle S1-151 | Talks by Awardees – Room S1-151

Sylvain Moineau [Université Laval], récipiendaire du prix "Scientifique chevronné de Canadian Science Publishing" | "Canadian Science Publishing Senior Investigator" Awardee
Phages and CRISPR-Cas Systems: The ongoing battle

17:00 - 17:15 Remise de prix pour présentations par affiches – Salle S1-151| Announcement of Poster Prizes– Room S1-151

17:15 - 17:30 Mot de clôture– Salle S1-151 | Closing remarks – Room S1-151
Imogen Coe, Vice-Présidente de la SCBM | CSMB Vice-President