Users will be able to access their posters to test the presentation mode.

Opening remarks by the planning committee: Nicole Perry-Hauser, Brian Bender, Andreas Bock, Desislava Nesheva, and Martha Sommer

Short talks by ECIs selected from abstracts Chairs: Brian Bender and Desislava Nesheva Sponsored by 7TM Antibodies Noncanonical interactions of G proteins and β‐arrestins: from competitors to companions Presented by Jeffery S. Smith GRK2/3 overexpression negatively influences Gq coupled signaling Presented by Natasha Jaiswal Dissociation of the intramolecularly cleaved N- and C-terminal fragments of the adhesion G protein-coupled receptor GPR133 (ADGRD1) increases its canonical signaling in glioblastoma. Presented by Joshua Frenster View Recording (Opening & Session 1) (same passcode as session)

Short talks by ECIs selected from abstracts Chairs: Nicole Perry-Hauser and Andreas Bock How may GPCR dimers get activated? Insights from cryo-EM snapshots of the entire class D1 GPCR activation pathway Presented by Vaithish Velazhahan Active state structures of the melanocortin-4 receptor-Gs complex bound with agonists NDP-α-MSH and setmelanotide Presented by Nicolas Heyder Structural insights into G-protein coupled receptor activation Presented by Kaavya Krishna Kumar View Recording (same passcode as session)

Taste GPCRs and their Ligands Masha Niv, Hebrew Institute of Jerusalem Chair: Brian Bender View Recording (same passcode as session)

ECIs will be grouped with various GPCR leaders for an informal lunch session. Attendees are encouraged to ask questions about career paths/job opportunities/etc.

Short talks by ECIs selected from abstracts Chairs: Nicole Perry-Hauser and Andreas Bock Opsin 3 regulates melanocortin receptor signaling Presented by Hala Haddad Analyzing the Internalization Behavior of Chemerin 9 and the CMKLR1 Receptor to Establish a Peptide Based Shuttling System Presented by Anne Sophie Czerniak Approaches to Dissect the Role of Endosome Positioning in Spatially Encoded GPCR Signaling Presented by Blair Willette Single molecule and fluorescence spectroscopy analyses reveal dynamic and ligand-sensitive dimerization of CXCR4 Presented by Ali Isbilir View Recording Part 1 (same passcode as session) View Recording Part 2 (same passcode as session)

Laura Bohn, Scripps Research

Martin Lohse, ISAR Bioscience, Munich, Germany

Mark von Zastrow, UCSF

Fiona Marshall, Merck

Even-numbered poster submissions Sponsors: ACS Pharmacology & Translational Science and Excellerate Biosciences

Odd-numbered poster submissions Sponsor: ACS Pharmacology & Translational Science

Laura Wingler, Duke Chair: Andreas Bock Sponsor: ACS Pharmacology & Translational Science View Recording (Keynote II & Closing) (same passcode as session)

Closing remarks from the symposium committee and prizes for posters