Tuesday, June 21

13:00-16:00 -- Registration (Outside rooms Noviciat 1-2)

13:00-16:00 -- Visit of the historical Monastery of the Augustine Sisters (two groups of 25 people max.) The activity is covered by the organization but registration is required.

13:30-14:30 -- Group 1

14:30-15:30 -- Group 2

* All workshops and keynote presentations will be in rooms Noviciat 1-2 *

16:00-16:15 -- Opening Remarks

16:15-17:45 -- Workshop 1 “The physiological outcome of deamination: somatic hypermutation and class switch recombination”

Session Chair: David Schatz

16:15-16:45 -- David Schatz - HMCES acts to suppress deletions during somatic hypermutation

16:45-17:05 -- Anjana Rao - Two new putative Aicda enhancers

17:05-17:25 -- Uttiya Basu - Acquired somatic hypermutation at super-enhancer embedded DNA regulatory elements during B cell lymphoma progression

17:25-17:45 -- Kefei Yu - AID footprints at switch regions during class switch recombination

17:45-19:00 -- Dinner (Room Communauté) + Free Time

19:00-20:00 -- Keynote I - Dr Michel Nussensweig “Generating therapeutic antibodies”

20:00 -- Welcoming Gathering

Wednesday, June 22

7:00-8:30 -- Breakfast (Réfectoire historique)

8:30-10:00 -- Workshop 2 “Innate immunity by APOBEC deaminases”

Session Chair: Michael Malim

8:30-9:00 -- Michael Malim- APOBEC3 restriction of HIV infection

9:00-9:20 -- Linda Chelico - Protein interaction map of APOBEC3 enzyme family reveals deamination-independent role in cellular function

9:20-9:40 -- Susan Ross - The Role of UNG in Repair of APOBEC3G – Mediated Mutation of Retroviruses

9:40-10:00 -- Marc Andre Langlois- Host restriction factors APOBEC3F and APOBEC3G alter HIV integration site profiles in the human genome - a potential new cause for HIV proviral latency?

10:00-10:30 -- Coffee break

10:30–12:00 -- Workshop 3 “Regulation of genomic deamination”

Session Chair: Amy Kenter

10:30-11:00 -- Amy Kenter- An extremely surprising B cell intermediate of CSR

11:00-11:20 -- Bao Vuong - Functions of Phosphorylated AID in Class Switch Recombination

11:20-11:40 -- Silvestro Conticello - Induction of extrachromosomal DNA by the APOBECs

11:40-12:00 -- Farazul Haque - The Role of Mediator in Class Switch Recombination

12:00-13:30 -- Lunch (Room Communauté) + Free time

13:30-15:00-- Workshop 4 “DNA repair during Antibody Diversification”

Session chair: Maki Kobayashi

13:30-14:00 -- Maki Kobayashi - The reduction of DNA top 1 enhances DNA breaks in Ig gene rearrangement and is regulated by a miRNA and Ago2

14:00-14:20 -- Ashok Bhagwat - Uracilome of Cells Undergoing Class-switch Recombination

14:20-14:40 -- Javier Di Noia – The cellular microenvironment of AID

14:40-15:00 -- Bernardo Reina San Martin - Fam72a controls the balance between error-prone and error-free DNA repair during antibody diversification

15:20-17:10 -- “Poster Presentations” * at the Voûtes/vaults * (Coffee and snacks available)

17:10-17:30 -- Group photo

17:30-18:30 -- Keynote II - Fred Alt “The genomic landscape during antibody diversification”

18:30-20:00 -- Dinner (Room Communauté)

20:00 -- Pub outing in Old Quebec City (Optional, everybody welcomed)

Thursday, June 23

7:00-8:30 -- Breakfast (@ Réfectoire historique)

8:30-10:00 -- Workshop 5 “Regulation of AID, somatic hypermutation and class switch recombination”

Session chair: Pat Gearhart

8:30-9:00 -- Pat Gearhart - Targeting AID to Variable Regions

9:00-9:20 -- Michel Cogne - Alternate AID-induced breaks in human Ig genes

9:20-9:40 -- Mani Larijani - Structural characterization of AID: a journey into the fifth dimension

9:40-10:00 -- Rushad Pavri - Principles of 3D locus architecture underlying SHM - insights from the human IGH locus

10:00-10:30 -- Coffee break

10:30-12:20 -- Workshop 6 “Regulation of B cell biology”

Session Chair: Michela Di Virgilio

10:30-11:00 -- Michela Di Virgilio - Temporal Control of Individual Steps in Igh Switching: modeling CSR for in silico transcriptomics screening

11:00-11:20 -- Jean Philippe Julien - Antibody homotypic interactions in the recognition of malaria CSP repeat antigens

11:20-11:40 -- Alexandre Orthwein - The dUB Otub1 regulates B-cell chemotactic response by modulating the stability of the gamma subunit Gng2

11:40-12:00 -- Jayanta Chaudhuri - AID mutations, G4s and viral immunity

12:00-13:30 -- Lunch (Room Communauté) + Free time

13:30-15:20 -- Workshop 7 “Deamination in Disease: Immune pathologies and cancer”

Session Chair: Qiang Pan Hammarstrom

13:30-14:00 -- Qiang Pan Hammarstrom - AID dependent- and independent mechanisms of mutagenesis in human B-cell lymphoma

14:00-14:20 -- Sergio Roa - The double-edge role of AID in B-cell lymphoma progression and immunotherapy

14:20-14:40 -- Almudena Ramiro - Antibodies meet the atheroma plaque: an immunologist’s journey

14:40-15:00 -- Remi Buisson - APOBEC3B drives innate immune responses against viral infection

15:00-15:20 -- Alberto Martin - FAM72 in B cell biology and cancer

15:20 -18:00 -- Social & free time

18:00 -- Closing Dinner

Photos