Tuesday, June 21
13:00-16:00 -- Registration (Outside rooms Noviciat 1-2)
13:00-16:00 -- Visit of the historical Monastery of the Augustine Sisters (two groups of 25 people max.) The activity is covered by the organization but registration is required.
13:30-14:30 -- Group 1
14:30-15:30 -- Group 2
*** All workshops and keynote presentations will be in rooms Noviciat 1-2 ***
16:00-16:15 -- Opening Remarks
16:15-17:45 -- Workshop 1 “The physiological outcome of deamination: somatic hypermutation and class switch recombination”
Session Chair: David Schatz
16:15-16:45 -- David Schatz - HMCES acts to suppress deletions during somatic hypermutation
16:45-17:05 -- Anjana Rao - Two new putative Aicda enhancers
17:05-17:25 -- Uttiya Basu - Acquired somatic hypermutation at super-enhancer embedded DNA regulatory elements during B cell lymphoma progression
17:25-17:45 -- Kefei Yu - AID footprints at switch regions during class switch recombination
17:45-19:00 -- Dinner (Room Communauté) + Free Time
19:00-20:00 -- Keynote I - Dr Michel Nussensweig “Generating therapeutic antibodies”
20:00 -- Welcoming Gathering
Wednesday, June 22
7:00-8:30 -- Breakfast (Réfectoire historique)
8:30-10:00 -- Workshop 2 “Innate immunity by APOBEC deaminases”
Session Chair: Michael Malim
8:30-9:00 -- Michael Malim- APOBEC3 restriction of HIV infection
9:00-9:20 -- Linda Chelico - Protein interaction map of APOBEC3 enzyme family reveals deamination-independent role in cellular function
9:20-9:40 -- Susan Ross - The Role of UNG in Repair of APOBEC3G – Mediated Mutation of Retroviruses
9:40-10:00 -- Marc Andre Langlois- Host restriction factors APOBEC3F and APOBEC3G alter HIV integration site profiles in the human genome - a potential new cause for HIV proviral latency?
10:00-10:30 -- Coffee break
10:30–12:00 -- Workshop 3 “Regulation of genomic deamination”
Session Chair: Amy Kenter
10:30-11:00 -- Amy Kenter- An extremely surprising B cell intermediate of CSR
11:00-11:20 -- Bao Vuong - Functions of Phosphorylated AID in Class Switch Recombination
11:20-11:40 -- Silvestro Conticello - Induction of extrachromosomal DNA by the APOBECs
11:40-12:00 -- Farazul Haque - The Role of Mediator in Class Switch Recombination
12:00-13:30 -- Lunch (Room Communauté) + Free time
13:30-15:00-- Workshop 4 “DNA repair during Antibody Diversification”
Session chair: Maki Kobayashi
13:30-14:00 -- Maki Kobayashi - The reduction of DNA top 1 enhances DNA breaks in Ig gene rearrangement and is regulated by a miRNA and Ago2
14:00-14:20 -- Ashok Bhagwat - Uracilome of Cells Undergoing Class-switch Recombination
14:20-14:40 -- Javier Di Noia – The cellular microenvironment of AID
14:40-15:00 -- Bernardo Reina San Martin - Fam72a controls the balance between error-prone and error-free DNA repair during antibody diversification
15:20-17:10 -- “Poster Presentations” *** at the Voûtes/vaults *** (Coffee and snacks available)
17:10-17:30 -- Group photo
17:30-18:30 -- Keynote II - Fred Alt “The genomic landscape during antibody diversification”
18:30-20:00 -- Dinner (Room Communauté)
20:00 -- Pub outing in Old Quebec City (Optional, everybody welcomed)
Thursday, June 23
7:00-8:30 -- Breakfast (@ Réfectoire historique)
8:30-10:00 -- Workshop 5 “Regulation of AID, somatic hypermutation and class switch recombination”
Session chair: Pat Gearhart
8:30-9:00 -- Pat Gearhart - Targeting AID to Variable Regions
9:00-9:20 -- Michel Cogne - Alternate AID-induced breaks in human Ig genes
9:20-9:40 -- Mani Larijani - Structural characterization of AID: a journey into the fifth dimension
9:40-10:00 -- Rushad Pavri - Principles of 3D locus architecture underlying SHM - insights from the human IGH locus
10:00-10:30 -- Coffee break
10:30-12:20 -- Workshop 6 “Regulation of B cell biology”
Session Chair: Michela Di Virgilio
10:30-11:00 -- Michela Di Virgilio - Temporal Control of Individual Steps in Igh Switching: modeling CSR for in silico transcriptomics screening
11:00-11:20 -- Jean Philippe Julien - Antibody homotypic interactions in the recognition of malaria CSP repeat antigens
11:20-11:40 -- Alexandre Orthwein - The dUB Otub1 regulates B-cell chemotactic response by modulating the stability of the gamma subunit Gng2
11:40-12:00 -- Jayanta Chaudhuri - AID mutations, G4s and viral immunity
12:00-13:30 -- Lunch (Room Communauté) + Free time
13:30-15:20 -- Workshop 7 “Deamination in Disease: Immune pathologies and cancer”
Session Chair: Qiang Pan Hammarstrom
13:30-14:00 -- Qiang Pan Hammarstrom - AID dependent- and independent mechanisms of mutagenesis in human B-cell lymphoma
14:00-14:20 -- Sergio Roa - The double-edge role of AID in B-cell lymphoma progression and immunotherapy
14:20-14:40 -- Almudena Ramiro - Antibodies meet the atheroma plaque: an immunologist’s journey
14:40-15:00 -- Remi Buisson - APOBEC3B drives innate immune responses against viral infection
15:00-15:20 -- Alberto Martin - FAM72 in B cell biology and cancer
15:20 -18:00 -- Social & free time
18:00 -- Closing Dinner
