April 23, 2023
14:00 - 17:30 | Registration (Max Bell Central Foyer)
14:00 - 17:30 | Poster set-up (rooms MB 251, MB 252, MB 253) *
17:30 - 19:00 | Dinner (Vistas Room)
* Posters should remain up for the entire meeting.
19:00 - 19:30 | Opening remarks and Tony Pawson retrospective
(Max Bell Auditorium)
Tony Pawson Keynote Lecture
(Max Bell Auditorium)
Chairpersons: Jean-François Côté, PhD; Michael Gold, PhD; and Nina Jones, PhD
19:30 - 20:30
Marc Therrien, PhD
Professor, Department of Pathology and Cell Biology of the Faculty of Medicine of the Université de Montréal and Scientific Director of IRIC
From flies to humans: deciphering the inner workings of the RAS-MAPK pathway
20:30 – 21:00 | Juliet Daniel, PhD
Professor and Associate Dean of Research & External Relations, McMaster University
What’s Kaiso got to do with it (TNBC)?
21:00 - 21:30 - Social time
April 24, 2023
7:00 - 8:30
Breakfast (Vistas Room)
8:30 – 12:00 | SESSION 1: Signalling in the Tumor Microenvironment
(Max Bell Auditorium)
Chairpersons:
Donna Senger, PhD Associate Member, Department of Medicine, Division of Experimental Medicine; Associate Professor - Department of OncologyMcGill University
Susan Logue, PhD, Assistant professor, Max Rady College of Medicine, Human anatomy and cell science, University of Manitoba
8:30 - 9:00 | Calvin Roskelley, PhD
Faculty of Medicine, Department of Cellular & Physiological Sciences, UBC
Metastatic colonization of the lung is facilitated by inflammatory-derived monocyte-derived macrophages
9:00 – 9:30 | Bebhinn Treanor, PhD
Associate Professor, Canada Research Chair, Department of Biological Sciences, University of Toronto-Scarborough
Glycan-galectin interactions in the regulation of B cell activation and autoimmunity
9:30 - 9:45 | Andrew Craig, PhD
Associate Professor, Department of Biomedical and Molecular Sciences, Queen's University; Director, Queen's Cancer Research Institute, Principal Investigator, CBG Division Queen's University
Coordinated blockade of TGF-β and PD-L1 by bintrafusp alfa promotes survival in preclinical ovarian cancer models by promoting T effector memory responses
9:45 – 10:00 | Carrie Shemanko, PhD
Professor, Integrative Cell Biology, Biological Sciences, University of Calgary
From molecular mechanism to drug candidate and predictive testing, how we stop the vicious cycle of prolactin-accelerated breast cancer bone metastasis
10:00 – 10:30 | Coffee Break
(Max Bell Central Foyer)
10:30 – 11:00 | Sebastian Guettler, PhD
Deputy Head, Division of Structural Biology, The Institute of Cancer Research
Wnt/beta-catenin signalling: molecular mechanisms and regulation through ADP-ribosylation by tankyrase
11:00 – 11:30 | André Veillette, MD
Director, Molecular Oncology Research Unit, IRCM; Executive Director, Marathon of Hope Cancer Centres Network; Tier 1 Canada Research Chair in Immune System Signalling
Novel immune checkpoints in anti-tumor immunity
11:30 – 11:45 | Karla Williams, PhD
Assistant Professor, Faculty of Pharmaceutical Sciences UBC
Invadopodia Drive Tumor Cell Invasion into the Lymphatic System Promoting Metastasis to the Lymph Nodes and Lungs
11:45 - 12:00 | Sponsor's talk. Peter Hurley
Business Development Manager, Olink Proteomics
Empowering Genomics with Proteomics
12:00 - 15:00 | Lunch and free time
(Vistas Room)
15:00 - 15:45 | Lightning talks
15:45 - 17:30 | Poster session (ALL ODD NUMBERS)
(rooms MB 251, MB 252, MB 253)
17:30 - 19:00 | Dinner
(Vistas Room)
19:00 – 22:00 SESSION 2: Cell Cycle and Genome Stability
Chairpersons:
Nicolas Bisson, PhD, chercheur universitaire, Axe Oncologie, HDQ, Chaire de recherche du Canada en protéomique du cancer; professeur titulaire, Département de biologie moléculaire, biochimie médicale et pathologie, Faculté de médecine, Université Laval;
Edmond Chan, PhD, Assistant Professor, School of medicine, Department of Biomedical and Molecular Sciences, Queen's University
19:00 – 19:30 | Sabine Elowe, PhD
Full professor, Department of Pediatrics, Faculty of Medicine, Université Laval
ARHGEF17: A driver of cell cycle progression and mitotic fidelity
19:30 - 20:00 | Lisa Porter, PhD
Professor, Department of Biomedical Sciences, University of Windsor; Executive Director, WE-SPARK Health Institute
Atypical Cell Cycle Regulation in Liver Homeostasis: Implications in the Progression to Hepatocellular Carcinoma
20:00 – 20:30 | Coffee Break
(Max Bell Central Foyer)
20:30 – 21:00 | Sébastien Carreno, PhD
Principal Investigator, Cellular Mechanisms of Morphogenesis during Mitosis and Cell Motility Research Unit, IRIC; Full Professor, Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal
Exploring the dynamic control of cell morphogenesis in mitosis
21:00 - 21:30 | Savraj Grewal, PhD
Professor, Department of Biochemistry & Molecular Biology, University of Calgary
Innate immune signaling and the control of hypoxia adaptation in Drosophila
21:30 – 21:45 | Véronique Giroux, PhD
Professor, Faculté de médecine et des sciences de la santé, Université de Sherbrooke
Targeting stem cells to fight against anti-cancer treatment resistance
21:45 – 22:00 | Joel Pearson, PhD
Assistant professor, Max Rady College of Medicine, Pharmacology and Therapeutics, Department of Pharmacology and Therapeutics, University of Manitoba; CancerCare Manitoba Research Institute
Simplifying cancer: A single transcriptional complex stratifies cancers into just two types that interconvert to drive drug resistance
April 25, 2022
7:00 - 8:00
Breakfast (Vistas Room)
8:00 – 12:15 | SESSION 3: Signalling in Normal and Cancer Cells
(Max Bell Auditorium)
Chairpersons:
Robert Ingham, PhD, Associate Professor, Faculty of Medicine & Dentistry - Medical Microbiology and Immunology Department, University of Alberta
Perry Howard, PhD, Associate Professor and Chair of the Department, Biochemistry and Microbiology, University of Victoria
8:00 – 8:30 | Anne-Claude Gingras, PhD
Senior Investigator, Lunenfeld-Tanenbaum Research Institute
Exploring the spatio-temporal aspects of signal transduction
8:30 – 9:00 | Esther Verheyen, PhD
Professor, Molecular biology and biochemistry, Simon Fraser University
Integration of metabolic sensing with oncogenic signaling mechanisms in Drosophila tumour models
9:00 – 9:30 | Daniel Schramek, PhD
Investigator, Lunenfeld-Tanenbaum Research Institute; Associate Professor, Dept. of Molecular Genetics, University of Toronto, Canadian Research Chair in Functional Cancer Genomics
In vivo veritas - using CRISPR technologies in mice to unravel novel cancer driver alterations in the non-coding genome.
9:30 - 10:00 | Coffee Break
(MB Central Foyer)
10:00 – 10:30 | Shoukat Dedhar, PhD
Professor, Biochemistry and Molecular Biology; Professor, Genetics Graduate Program; Senior Scientist, British Columbia Cancer Agency / British Columbia Cancer Research Centre
Death by Iron accumulation: Targeting the CAIX-NFS1/xCT axis in Hypoxic Solid Tumors
10:30 – 11:00 | Silvia Penuela, PhD
Associate Professor, Anatomy and Cell Biology, University of Western Ontario
Pannexin channels in cancer regulation through Wnt signalling
11:00 – 11:30 | Robert Rottapel, PhD
Professor, Departments of Medicine, Immunology and Medical Biophysics, University of Toronto; Senior Investigator, OICR; Co-Leader, Ovarian Cancer Translational Research Initiative; Senior Scientist and Amgen Chair for Cancer Research, Princess Margaret Cancer Centre
Emergent Adaptive Pathways in High Grade Serous Ovarian Cancer
11:30 – 11:45 | Wei Zhang, PhD
Assistant Professor and CIFAR Global Scholar, Department of Molecular and Cellular Biology, University of Guelph
Targeted protein degradation by ubiquitin variant induced proximity
11:45 – 12:00 | Mohan Malleshaiah, PhD
Assistant Research Professor, IRCM; Assistant Research Professor, Department of Biochemistry and Molecular Medicine, Université de Montréal; Adjunct Member, Division of Experimental Medicine in the Department of Medicine, McGill University
Altering stem cell states by controlling cell signalling information
12:00 – 12:15 | Sponsor’s talk
STEMCELL
12:15 - 15:00 | Lunch and free time
(Vistas Room)
15:00 - 15:45 | Lightning talks
15:45 - 17:30 | Poster session (ALL EVEN NUMBERS)
(rooms MB 251, MB 252, MB 253)
17:30 - 19:00 | Dinner
(Vistas Room)
19:00 – 22:00 | MOHCCN Session #1
Improving Outcomes of Hard-to-Treat Cancer with Precision Oncology
(Max Bell Auditorium)
Chairpersons:
André Veillette, MD, Director, Molecular Oncology Research Unit, IRCM; Executive Director, Marathon of Hope Cancer Centres Network; Tier 1 Canada Research Chair in Immune System Signalling
James Woodgett, PhD, President and Scientific Director, Terry Fox Research Institute Professor; Senior Scientist at Mount Sinai Hospital (Toronto), Sinai Health System
19:00 – 19:30 | Alexandre Orthwein, PhD*
Assistant Professor Department of Radiation Oncology ⎜Emory University School of Medicine Winship Cancer Institute of Emory University
Identification of novel DNA repair factors with prognostic potential using multi-omics data integration analysis
19:30 – 20:00 | Janessa Laskin, MD, FRCPC*
Clinical Associate Professor, Medical Oncology, University of British Columbia
Integrating State-of-the-Art Genomic Technology into Cancer Care
20:00 – 20:30 | Coffee Break
(Max Bell Central Foyer)
20:30 - 21:00 | Trevor Pugh, PhD, FACMG*
Senior Scientist, Princess Margaret Cancer Centre
Using Cancer Genomes as Spotlights to Search for Minimal Residual Disease in Cell-free DNA
21:00 – 21:30 | Morag Park, PhD*
Professor, Department of Biochemistry and Director, Rosalind and Morris Goodman Cancer Centre, McGill University
Unleashing the Molecular Mysteries of METex14del: Paving the Way for Personalized Cancer Therapies
21:30 – 22:00 | Marathon of Hope Cancer Centres Network
André Veillette, Isabel Serrano, Natalie Szudy
An introduction to the Marathon of Hope Cancer Centres Network, Team Canada advancing Precision Medicine for cancer patients and opportunities for collaboration
April 26, 2023
7:00 - 8:00
Breakfast (Vistas Room)
8:00 – 12:00 | SESSION 4: Kinases and Ras proteins
Chairpersons:
Costin Antonescu, PhD, Professor, Undergraduate Program Director and Biology Co-op, Advisor Dimensions Chair, Faculty of Science, Toronto Metropolitan University;
David Hipfner, PhD, Associate Research Professor, IRCM; Associate Research Professor, Department of Medicine (accreditation in molecular biology), Université de Montréal; Adjunct Professor, Department of Biology and Division of Experimental Medicine, McGill University
8:00 – 8:30 | Matt Smith, PhD
Principal Investigator, Cancer Signalling and Structural Biology Research Unit, IRIC; Associate Professor, Department of Pathology and Cell Biology, Université de Montréal
Complexities in RAS GTPase Signalling to Effector Proteins
8:30 – 9:00 | James Murphy, PhD
Professor, Head, Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Australia
Licence to kill: understanding how the zombie protein, MLKL, is triggered to kill cells by necroptosis
9:00 – 9:30 | Nathalie Lamarche-Vane, PhD
Professor, Anatomy and Cell Biology, McGill University
CdGAP is a molecular target of TGFb signaling involved in development and diseases
9:30 – 10:00 Coffee Break
(MB Central Foyer)
10:00 – 10:30 | Lois Mulligan, PhD
Professor, Pathology and Molecular Medicine, Queen’s University
Slow traffic ahead: Driving cancer through altered membrane dynamics
10:30 – 11:00 | Michael Olson, PhD
Professor, Department of Chemistry and Biology, Toronto Metropolitan University; Tier 1 Canada Research Chair in Molecular Cell Biology
ROCK1 and apoptotic blebbing: What is it good for?
11:00 – 11:30 | James Woodgett, PhD*
President and Scientific Director, Terry Fox Research Institute Professor; Senior Scientist at Mount Sinai Hospital (Toronto), Sinai Health System
Robustness in developmental signaling vs sledgehammer signaling in cancer
11:30 – 11:45 | Mélanie Laurin, PhD
Chercheure, Axe Oncologie, HDQ; professeure adjointe, Département biologie moléculaire, biochimie médicale et pathologie, Faculté de médecine, Université Laval
The RhoGEF FGD1 regulates skin morphogenesis
11:45 – 12:00 | Valentin Jaumouillé, PhD
Assistant Professor, Department of Molecular Biology and Biochemistry, Simon Fraser University
Actin dynamics and mechanosensing in integrin-mediated phagocytosis
12:00 - 13:30 | Lunch and free time
(Vistas Room)
13:30 – 15:30 | MOHCCN Session #2
Immune Regulation of Cancer Progression
(Max Bell Auditorium)
Chairpersons:
André Veillette, MD, Director, Molecular Oncology Research Unit, IRCM; Executive Director, Marathon of Hope Cancer Centres Network; Tier 1 Canada Research Chair in Immune System Signalling
James Woodgett, PhD, President and Scientific Director, Terry Fox Research Institute Professor; Senior Scientist at Mount Sinai Hospital (Toronto), Sinai Health System
13:30 – 14:00 | Enfu Hui, PhD*
Associate Professor, Department of Cell and Developmental Biology, University of California, San Diego, USA
Cis-signaling of the T cell costimulatory receptor CD28
14:00 – 14:30 | Brad Nelson, PhD*
Professor, Medical Genetics, University of British Columbia
Deciphering and re-engineering the immune response to cancer
14:30 – 15:00 | Ian Watson, PhD*
Associate Professor, Department of Biochemistry, McGill University
The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma
15:00 – 15:30 | Daniela Quail, PhD*
Assistant Professor, Rosalind and Morris Goodman Cancer Centre and the Department of Physiology, McGill University
Fueling cancer through the tumour immune microenvironment
15:30 – 16:30 | MOHCCN Closing session
(Max Bell Auditorium)
Chairpersons:
André Veillette, MD, Director, Molecular Oncology Research Unit, IRCM; Executive Director, Marathon of Hope Cancer Centres Network; Tier 1 Canada Research Chair in Immune System Signalling
James Woodgett, PhD, President and Scientific Director, Terry Fox Research Institute Professor; Senior Scientist at Mount Sinai Hospital (Toronto), Sinai Health System
Marco Marra, PhD, FRS(C), FCAHS, OBC*
Professor, Department of Medical Genetics, University of British Columbia
The genomics of treatment resistant cancers
19:00 | Banquet
(Kinnear Centre - KC 303)
April 27, 2023
7:00 - 9:00
Breakfast (Vistas Room) - Departure
* Speakers supported by TFRI/MOHCCN.
