Name: 12th Signalling in Normal and Cancer Cells Conference - Banff
Start: 2023-04-23T21:00:00Z
End: 2023-04-27T15:00:00Z
Location: Banff Centre for Arts and Creativity

April 23, 2023

14:00 - 17:30 | Registration (Max Bell Central Foyer)

14:00 - 17:30 | Poster set-up (rooms MB 251, MB 252, MB 253) *

17:30 - 19:00 | Dinner (Vistas Room)

* Posters should remain up for the entire meeting.

19:00 - 19:30 | Opening remarks and Tony Pawson retrospective

(Max Bell Auditorium)

Tony Pawson Keynote Lecture

(Max Bell Auditorium)

Chairpersons: Jean-François Côté, PhD; Michael Gold, PhD; and Nina Jones, PhD

19:30 - 20:30

Marc Therrien, PhDProfessor, Department of Pathology and Cell Biology of the Faculty of Medicine of the Université de Montréal and Scientific Director of IRIC

From flies to humans: deciphering the inner workings of the RAS-MAPK pathway

20:30 – 21:00 | Juliet Daniel, PhDProfessor and Associate Dean of Research & External Relations, McMaster University

What’s Kaiso got to do with it (TNBC)?

21:00 - 21:30 - Social time

April 24, 2023

7:00 - 8:30
Breakfast (Vistas Room)

8:30 – 12:00 | SESSION 1: Signalling in the Tumor Microenvironment

(Max Bell Auditorium)

Chairpersons:

Donna Senger, PhD Associate Member, Department of Medicine, Division of Experimental Medicine; Associate Professor - Department of OncologyMcGill University

Susan Logue, PhD, Assistant professor, Max Rady College of Medicine, Human anatomy and cell science, University of Manitoba

8:30 - 9:00 | Calvin Roskelley, PhDFaculty of Medicine, Department of Cellular & Physiological Sciences, UBC

Metastatic colonization of the lung is facilitated by inflammatory-derived monocyte-derived macrophages

9:00 – 9:30 | Bebhinn Treanor, PhDAssociate Professor, Canada Research Chair, Department of Biological Sciences, University of Toronto-Scarborough

Glycan-galectin interactions in the regulation of B cell activation and autoimmunity

9:30 - 9:45 | Andrew Craig, PhDAssociate Professor, Department of Biomedical and Molecular Sciences, Queen's University; Director, Queen's Cancer Research Institute, Principal Investigator, CBG Division Queen's University

Coordinated blockade of TGF-β and PD-L1 by bintrafusp alfa promotes survival in preclinical ovarian cancer models by promoting T effector memory responses

9:45 – 10:00 | Carrie Shemanko, PhDProfessor, Integrative Cell Biology, Biological Sciences, University of Calgary

From molecular mechanism to drug candidate and predictive testing, how we stop the vicious cycle of prolactin-accelerated breast cancer bone metastasis

10:00 – 10:30 | Coffee Break

(Max Bell Central Foyer)

10:30 – 11:00 | Sebastian Guettler, PhDDeputy Head, Division of Structural Biology, The Institute of Cancer Research

Wnt/beta-catenin signalling: molecular mechanisms and regulation through ADP-ribosylation by tankyrase

11:00 – 11:30 | André Veillette, MDDirector, Molecular Oncology Research Unit, IRCM; Executive Director, Marathon of Hope Cancer Centres Network; Tier 1 Canada Research Chair in Immune System Signalling

Novel immune checkpoints in anti-tumor immunity

11:30 – 11:45 | Karla Williams, PhDAssistant Professor, Faculty of Pharmaceutical Sciences UBC

Invadopodia Drive Tumor Cell Invasion into the Lymphatic System Promoting Metastasis to the Lymph Nodes and Lungs

11:45 - 12:00 | Sponsor's talk. Peter HurleyBusiness Development Manager, Olink Proteomics

Empowering Genomics with Proteomics

12:00 - 15:00 | Lunch and free time

(Vistas Room)

15:00 - 15:45 | Lightning talks

15:45 - 17:30 | Poster session (ALL ODD NUMBERS)

(rooms MB 251, MB 252, MB 253)

17:30 - 19:00 | Dinner

(Vistas Room)

19:00 – 22:00 SESSION 2: Cell Cycle and Genome Stability

Chairpersons:

Nicolas Bisson, PhD, chercheur universitaire, Axe Oncologie, HDQ, Chaire de recherche du Canada en protéomique du cancer; professeur titulaire, Département de biologie moléculaire, biochimie médicale et pathologie, Faculté de médecine, Université Laval;

Edmond Chan, PhD, Assistant Professor, School of medicine, Department of Biomedical and Molecular Sciences, Queen's University

19:00 – 19:30 | Sabine Elowe, PhDFull professor, Department of Pediatrics, Faculty of Medicine, Université Laval

ARHGEF17: A driver of cell cycle progression and mitotic fidelity

19:30 - 20:00 | Lisa Porter, PhDProfessor, Department of Biomedical Sciences, University of Windsor; Executive Director, WE-SPARK Health Institute

Atypical Cell Cycle Regulation in Liver Homeostasis: Implications in the Progression to Hepatocellular Carcinoma

20:00 – 20:30 | Coffee Break

(Max Bell Central Foyer)

20:30 – 21:00 | Sébastien Carreno, PhDPrincipal Investigator, Cellular Mechanisms of Morphogenesis during Mitosis and Cell Motility Research Unit, IRIC; Full Professor, Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal

Exploring the dynamic control of cell morphogenesis in mitosis

21:00 - 21:30 | Savraj Grewal, PhDProfessor, Department of Biochemistry & Molecular Biology, University of Calgary

Innate immune signaling and the control of hypoxia adaptation in Drosophila

21:30 – 21:45 | Véronique Giroux, PhDProfessor, Faculté de médecine et des sciences de la santé, Université de Sherbrooke

Targeting stem cells to fight against anti-cancer treatment resistance

21:45 – 22:00 | Joel Pearson, PhDAssistant professor, Max Rady College of Medicine, Pharmacology and Therapeutics, Department of Pharmacology and Therapeutics, University of Manitoba; CancerCare Manitoba Research Institute

Simplifying cancer: A single transcriptional complex stratifies cancers into just two types that interconvert to drive drug resistance

April 25, 2022

7:00 - 8:00
Breakfast (Vistas Room)

8:00 – 12:15 | SESSION 3: Signalling in Normal and Cancer Cells

(Max Bell Auditorium)

Chairpersons:

Robert Ingham, PhD, Associate Professor, Faculty of Medicine & Dentistry - Medical Microbiology and Immunology Department, University of Alberta

Perry Howard, PhD, Associate Professor and Chair of the Department, Biochemistry and Microbiology, University of Victoria

8:00 – 8:30 | Anne-Claude Gingras, PhDSenior Investigator, Lunenfeld-Tanenbaum Research Institute

Exploring the spatio-temporal aspects of signal transduction

8:30 – 9:00 | Esther Verheyen, PhDProfessor, Molecular biology and biochemistry, Simon Fraser University

Integration of metabolic sensing with oncogenic signaling mechanisms in Drosophila tumour models

9:00 – 9:30 | Daniel Schramek, PhDInvestigator, Lunenfeld-Tanenbaum Research Institute; Associate Professor, Dept. of Molecular Genetics, University of Toronto, Canadian Research Chair in Functional Cancer Genomics

In vivo veritas - using CRISPR technologies in mice to unravel novel cancer driver alterations in the non-coding genome.

9:30 - 10:00 | Coffee Break

(MB Central Foyer)

10:00 – 10:30 | Shoukat Dedhar, PhDProfessor, Biochemistry and Molecular Biology; Professor, Genetics Graduate Program; Senior Scientist, British Columbia Cancer Agency / British Columbia Cancer Research Centre

Death by Iron accumulation: Targeting the CAIX-NFS1/xCT axis in Hypoxic Solid Tumors

10:30 – 11:00 | Silvia Penuela, PhDAssociate Professor, Anatomy and Cell Biology, University of Western Ontario

Pannexin channels in cancer regulation through Wnt signalling

11:00 – 11:30 | Robert Rottapel, PhDProfessor, Departments of Medicine, Immunology and Medical Biophysics, University of Toronto; Senior Investigator, OICR; Co-Leader, Ovarian Cancer Translational Research Initiative; Senior Scientist and Amgen Chair for Cancer Research, Princess Margaret Cancer Centre

Emergent Adaptive Pathways in High Grade Serous Ovarian Cancer

11:30 – 11:45 | Wei Zhang, PhDAssistant Professor and CIFAR Global Scholar, Department of Molecular and Cellular Biology, University of Guelph

Targeted protein degradation by ubiquitin variant induced proximity

11:45 – 12:00 | Mohan Malleshaiah, PhDAssistant Research Professor, IRCM; Assistant Research Professor, Department of Biochemistry and Molecular Medicine, Université de Montréal; Adjunct Member, Division of Experimental Medicine in the Department of Medicine, McGill University

Altering stem cell states by controlling cell signalling information

12:00 – 12:15 | Sponsor’s talk STEMCELL

12:15 - 15:00 | Lunch and free time

(Vistas Room)

15:00 - 15:45 | Lightning talks

15:45 - 17:30 | Poster session (ALL EVEN NUMBERS)

(rooms MB 251, MB 252, MB 253)

17:30 - 19:00 | Dinner

(Vistas Room)

19:00 – 22:00 | MOHCCN Session #1

Improving Outcomes of Hard-to-Treat Cancer with Precision Oncology

(Max Bell Auditorium)

Chairpersons:

André Veillette, MD, Director, Molecular Oncology Research Unit, IRCM; Executive Director, Marathon of Hope Cancer Centres Network; Tier 1 Canada Research Chair in Immune System Signalling

James Woodgett, PhD, President and Scientific Director, Terry Fox Research Institute Professor; Senior Scientist at Mount Sinai Hospital (Toronto), Sinai Health System

19:00 – 19:30 | Alexandre Orthwein, PhD*Assistant Professor Department of Radiation Oncology ⎜Emory University School of Medicine Winship Cancer Institute of Emory University

Identification of novel DNA repair factors with prognostic potential using multi-omics data integration analysis

19:30 – 20:00 | Janessa Laskin, MD, FRCPC*Clinical Associate Professor, Medical Oncology, University of British Columbia

Integrating State-of-the-Art Genomic Technology into Cancer Care

20:00 – 20:30 | Coffee Break

(Max Bell Central Foyer)

20:30 - 21:00 | Trevor Pugh, PhD, FACMG*Senior Scientist, Princess Margaret Cancer Centre

Using Cancer Genomes as Spotlights to Search for Minimal Residual Disease in Cell-free DNA

21:00 – 21:30 | Morag Park, PhD*Professor, Department of Biochemistry and Director, Rosalind and Morris Goodman Cancer Centre, McGill University

Unleashing the Molecular Mysteries of METex14del: Paving the Way for Personalized Cancer Therapies

21:30 – 22:00 | Marathon of Hope Cancer Centres NetworkAndré Veillette, Isabel Serrano, Natalie Szudy

An introduction to the Marathon of Hope Cancer Centres Network, Team Canada advancing Precision Medicine for cancer patients and opportunities for collaboration

April 26, 2023

7:00 - 8:00
Breakfast (Vistas Room)

8:00 – 12:00 | SESSION 4: Kinases and Ras proteins

Chairpersons:

Costin Antonescu, PhD, Professor, Undergraduate Program Director and Biology Co-op, Advisor Dimensions Chair, Faculty of Science, Toronto Metropolitan University;

David Hipfner, PhD, Associate Research Professor, IRCM; Associate Research Professor, Department of Medicine (accreditation in molecular biology), Université de Montréal; Adjunct Professor, Department of Biology and Division of Experimental Medicine, McGill University

8:00 – 8:30 | Matt Smith, PhDPrincipal Investigator, Cancer Signalling and Structural Biology Research Unit, IRIC; Associate Professor, Department of Pathology and Cell Biology, Université de Montréal

Complexities in RAS GTPase Signalling to Effector Proteins

8:30 – 9:00 | James Murphy, PhDProfessor, Head, Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Australia

Licence to kill: understanding how the zombie protein, MLKL, is triggered to kill cells by necroptosis

9:00 – 9:30 | Nathalie Lamarche-Vane, PhDProfessor, Anatomy and Cell Biology, McGill University

CdGAP is a molecular target of TGFb signaling involved in development and diseases

9:30 – 10:00 Coffee Break

(MB Central Foyer)

10:00 – 10:30 | Lois Mulligan, PhDProfessor, Pathology and Molecular Medicine, Queen’s University

Slow traffic ahead: Driving cancer through altered membrane dynamics

10:30 – 11:00 | Michael Olson, PhDProfessor, Department of Chemistry and Biology, Toronto Metropolitan University; Tier 1 Canada Research Chair in Molecular Cell Biology

ROCK1 and apoptotic blebbing: What is it good for?

11:00 – 11:30 | James Woodgett, PhD*President and Scientific Director, Terry Fox Research Institute Professor; Senior Scientist at Mount Sinai Hospital (Toronto), Sinai Health System

Robustness in developmental signaling vs sledgehammer signaling in cancer

11:30 – 11:45 | Mélanie Laurin, PhDChercheure, Axe Oncologie, HDQ; professeure adjointe, Département biologie moléculaire, biochimie médicale et pathologie, Faculté de médecine, Université Laval

The RhoGEF FGD1 regulates skin morphogenesis

11:45 – 12:00 | Valentin Jaumouillé, PhDAssistant Professor, Department of Molecular Biology and Biochemistry, Simon Fraser University

Actin dynamics and mechanosensing in integrin-mediated phagocytosis

12:00 - 13:30 | Lunch and free time

(Vistas Room)

13:30 – 15:30 | MOHCCN Session #2

Immune Regulation of Cancer Progression

(Max Bell Auditorium)

Chairpersons:

André Veillette, MD, Director, Molecular Oncology Research Unit, IRCM; Executive Director, Marathon of Hope Cancer Centres Network; Tier 1 Canada Research Chair in Immune System Signalling

James Woodgett, PhD, President and Scientific Director, Terry Fox Research Institute Professor; Senior Scientist at Mount Sinai Hospital (Toronto), Sinai Health System

13:30 – 14:00 | Enfu Hui, PhD*Associate Professor, Department of Cell and Developmental Biology, University of California, San Diego, USA

Cis-signaling of the T cell costimulatory receptor CD28

14:00 – 14:30 | Brad Nelson, PhD*Professor, Medical Genetics, University of British Columbia

Deciphering and re-engineering the immune response to cancer

14:30 – 15:00 | Ian Watson, PhD*Associate Professor, Department of Biochemistry, McGill University

The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma

15:00 – 15:30 | Daniela Quail, PhD*Assistant Professor, Rosalind and Morris Goodman Cancer Centre and the Department of Physiology, McGill University

Fueling cancer through the tumour immune microenvironment

15:30 – 16:30 | MOHCCN Closing session

(Max Bell Auditorium)

Chairpersons:

André Veillette, MD, Director, Molecular Oncology Research Unit, IRCM; Executive Director, Marathon of Hope Cancer Centres Network; Tier 1 Canada Research Chair in Immune System Signalling

James Woodgett, PhD, President and Scientific Director, Terry Fox Research Institute Professor; Senior Scientist at Mount Sinai Hospital (Toronto), Sinai Health System