Schedule

Edit Buzás, MD, PhD - Professor at Semmelweis University, Budapest, Hungary, and a global leader in extracellular vesicle research. Novel Extracellular Vesicle Features in the Spotlight Chair: Melisa Gualdrón López

Speaker 7: Dr. Banquy Xavier (Department of Chemistry, University of Montreal, QC). - Shinning a new light on nanoparticles and EVs's nanointerface in biological media Speaker 8: Dr. Jacques Lapointe (Division of Clinical and Translational Research, McGill University, QC) - Exploring the diversity of extracellular particles released by prostate cancer cells Trainee Talk 7: Yunxi Chen (Cancer Research Program, Research Institute of the McGill University Health Centre, QC). Bottom-up synthesis of EV-mimetic vesicles with selective protein loading for modulating cell uptake and biodistribution. Trainee Talk 8: Andreas Wallucks (Department of Biomedical Engineering, McGill University, QC). Label-free sizing and multiplexed protein detection on single extracellular vesicles Chair: Dr. Dylan Burger / Co-chair: Gisela Strohle

Speaker 9: Dr. Jessie Lavoie (Department of Biochemistry, Microbiology and Immunology, University of Ottawa & Centre for Biologics Evaluation, Health Canada, ON) - Advancing Knowledge on Extracellular Vesicles in Cancer Immunotherapy: Exploring Their Potential in Targeting Triple-Negative Breast Cancer Speaker 10: Dr. Carolina Ilkow (Department of Biochemistry, Microbiology and Immunology, University of Ottawa & Ottawa Hospital Research Institute, ON) - Next Generation Cancer Therapies Using Viruses and Extracellular Vesicles Trainee Talk 9: Paula Quaglietta (Genetics and Genome Biology Program, The Hospital for Sick Children (SickKids), ON). Characterizing the secretome of the senescence-like primed state in Li-Fraumeni Syndrome Trainee Talk 10: Samia Jahouri (Faculty of Medicine and Health Sciences McGill University, QC). Elucidating the extracellular vesicle signature of K27M oncohistone-driven pediatric high-grade gliomas Chair: Dr. Alicia Viloria-Petit/ Co-chair: Modeline Longjohn

Speaker 11: Dr. Derrick Gibbings (Department of Cellular and Molecular Medicine University of Ottawa, ON). - Delivery of intracellular cargoes with extracellular vesicles in animal models Speaker 12: Dr. Dariusz Zurawek (Douglas Mental Health Institute, McGill University, QC).- The miRNA cargo of neuron-derived extracellular vesicles plays a role in mediating the antidepressant response. Trainee Talk 11: Frederic St-Denis-Bissonnette (Health Canada, University of Ottawa, ON). Natural killer cell-derived extracellular vesicles show therapeutic potential against triple-negative breast cancer. Trainee Talk 12: Thupten Tsering (McGill University, Research Institute of McGill University Health Centre, QC). Non-lytic and active emission of cellular fragments carrying whole genome DNA during cancer cell migration Chair: Corina Nagy / Co-chair: Boyang Su

Building the Future of EV Science in Canada: Training, Careers, and Translation Topics of discussion: · Training the Next Generation (i.e., training opportunities, building interdisciplinary skills, national programs) · Career Pathways in EV Science (i.e., academia, biotech/industry commercialization and/or entrepreneurship, government) · Mentorship and Development (i.e., mentorship beyond the lab, internships) · Canada on the Global EV Stage (i.e., talent retention, funding, collaborations, ISEV initiatives) Panelists: tba