Howard Fields, MD, PhD, Professor Emeritus, UCSF Weill Institute for Neurosciences Title: The Neurobiology of Opioid Analgesia: A Circuit Analytical Approach

Chair: Sam Ananthan, Chief, Chemistry and Pharmacology Branch, Division of Neuroscience and Behavior, NIDA Speakers: Manojkumar Puthenveedu, Professor, University of Michigan - Title: Subcellular location defines opioid receptor signaling outcome Mark Von Zastrow, Professor, USCF - Title: Compartmentalized signaling by opioid and related GPCRs Karen O'Malley , Professor, Washington University - Title: GPCR signaling from within the cell

Chair: Susruta Majumdar, Professor, Washington University Speakers: Jessica Anand, Research Assistant Professor, University of Michigan - Title: Design, synthesis and evaluation of mu opioid antagonists derived from the fentanyl template Jane Aldrich, Professor, University of Florida - Title: Development of peptidic kappa opioid receptor antagonists as potential treatments for substance abuse Andrew Riley, Assistant Professor, University of Illinois, Chicago - Title: Development of potent kappa agonists derived from picralima nitida alkaloids Susruta Majumdar, Professor, Washington University - Title: Structure based design of delta opioid agonist analgesics targeting the sodium site signaling by opioid and related GPCRs Hot Topic Speakers: Alexander Powell, Graduate student, University of Michigan - Title: A structure-activity exploration of positive allosteric modulators of the delta opioid receptor Loan Vu, Graduate student, University of Kentucky - Title: Searching for synthetic opioid rescue agents: identification of a potent opioid agonist with reduced respiratory depression

Chair: Jennifer Bossert, Staff Scientist, IRP/NIDA/NIH Speakers: Emmanuel Darcq, Universite de Strasbourgh-INSERM - Title: Opiate responsive neuronal circuitries in negative and positive affect Ginervra D'Ottavio, PhD candidate, University of Rome - Title: Pharmacokinetic correlates of heroin self-administration and their impact on social factors Giordano de Guglielmo, PhD, UCSD - Title: Individual and cellular variability in oxycodone addiction-like behaviors in outbred rats: The role of GABA and nociceptin systems Marie Eikemo, PhD, University of Oslo - Title: Stress-enhanced opioid self-administration in healthy men: A randomized controlled experimental medicine study Hot Topic Speaker: Samantha Dunn, Graduate student, Washington University - Title: Investigating the role of locus coeruleus mu opioid receptors in drug reward