Javier Gonzalez-Maeso, PhD, Professor, Virginia Commonwealth University Title: Molecular insights into psychedelic therapy mechanisms for opioid use disorder

Chair: Elyssa Margolis, Professor, USCF Discussant: Susan Ingram, Professor, University of Colorado Anschutz Speakers: Xiaoke Chen, Associate Professor, Stanford - Title: A closed-loop circuit for chronic mechanical pain Mary Heinricher, Professor, OHSU - Title: Pain-Modulating Circuits of the Rostral Ventromedial Medulla - A Circuit Analysis Elyssa Margolis, Professor, USCF - Title: The lateral habenula: a subcortical forebrain site for opioid action Hot Topic Speaker: Nicole Mercer Lindsay, Postdoctoral Fellow, Stanford University. - Title: Transcranial magnetic stimulation of motor cortex produces analgesia via opioidergic descending pain control circuits.

Chair: Saadet Inan, Senior Scientist, Temple University Speakers: Mark Ryan Oppenheimer, Graduate student, University of Miami - Title: Gut-brain axis in opioid use disorder Randall Davis, Professor, Oklahoma State University - Title: Modulation of neuroinflammatory signaling by the mu opioid receptor antagonist 6-funaltrexamine Saadet Inan, Senior scientist, Temple University - Title: Targeting IL-17A for chronic oxycodone-induced adverse effects Nadia Said, Postdoctoral fellow, NIDA - Title: A putative role of the neuroimmune system in heroin withdrawal Hot Topic Speaker: Chihiro Nozaki, Associate Professor, Waseda University - Title: “Anti-inflammatory” cannabinoid CB2 receptors enhanced high-fat diet evoked neuroinflammation in mice

Chairs: Erica Levitt, Associate Professor, University of Michigan, Elyssa Margolis, Professor, UCSF; Matthew O'Meara, Assistant Professor, University of Michigan Speakers: Gaspard Montandon, Assistant Professor, University of Toronto - Title: Neural mechanisms regulating opioid-induced respiratory depression and therapeutic strategies to reverse or prevent it Brian Ruyle, Postdoctoral Fellow, Washington University - Title: Peripheral opioid receptor antagonism attenuates fentanyl-induced cardiorespiratory depression and is devoid of aversive effects Ryan Phillips, Postdoc, University of Pittsburgh - Title: Disentangling descending pain modulation and respiratory control at the level of the rostral ventromedial medulla based on µ-opioid receptor expression Jay McLaughlin, Professor, University of Florida - Title: Kappa opioid receptor activation increases breathing rate Renata Marchette, Research Fellow, NIDA - Title: Understanding polydrug overdoses: additive effects and sex differences