Invited Speakers Cordula Enekel (University of Toronto) “Proteasome Dynamics” Maxime Rousseaux (University of Ottawa) “SUMOylation and protein homeostasis in response to cellular stress” Kalle Gehring (McGill University) “PRL protein phosphatases and cancer” Hilla Weidberg (University of British Columbia) “Activation of a mitochondria-to-nucleus signaling pathway by mis-targeted mitochondrial proteins” Selected short talks from abstracts Hossein Dvarinejad (University of Ottawa) “The Histone H3 Reader TONSOKU binds H3.1 Before and After Nucleosome Assembly” Ema Flores-Diaz (Université de Montréal) “MYC Degradation: An Actionable Vulnerability in T-Cell Leukemia” Trevor Morey (Western University) “SPAAC Pulse-Chase: A Novel Click Chemistry-based Method to Determine the Half-Life of Cellular Proteins”

Invited Speakers Kate Lee (University of Toronto) “Biomolecular condensate disassembly by molecular chaperones” Thibault Mayor (University of British Columbia) “Proteins losing it - what goes down first from stress to aging” Meredith Jackrel (Washington University in St. Louis) “Developing and applying protein disaggregases to counter protein misfolding” Michael Woodside (University of Alberta) “Prion-like conversion of SOD1 observed in single molecules using optical tweezers” Alex Parker (Université de Montréal) “Lipid metabolism, proteotoxicity and neurodegeneration in amyotrophic lateral sclerosis” Selected short talks from abstracts Alicia Dubinski (Université de Montréal) “Compromised stress granule response in the CNS of TDP-43 M337V mice” Arun Kumar (University of British Columbia) “DNA damage induced SUMOylation regulates intranuclear quality control in Saccharomyces cerevisiae” Kerry Sun (University of Alberta) “Alteration of tau aggregate structure mediated by disease-associated mutations”

Discussion of the future of PRinCE, including the 2025 meeting and a non-profit organization.