Day One: Monday June 24, 2024

8:00 - 9:00 Registration opens

9:00 - 16:30 Lessons learned from PERISCOPE

9:00-9:15 D. Diavatopoulos: The IMI-2 EU Project PERISCOPE

9:15 - 10:30 Chair: D. Diavatopulos - session I: Challenge Models

9:15-10:05 R. C. Read: Human Volunteer Challenge Studies

10:05-10:30 R. Le Grand: Baboon challenge model studies

10:30 - 11:00 Coffee Break

11:00 - 13:00 Chair: Beate Kampmann session II:

Maternal and Infant Vaccination Studies

11:00-11:30 Q. He: MIFI - Maternal pertussis Immunization in Finland study

11:30-12:10 D. Kelly: AWARE - Acellular versus Whole cell pertussis vaccine - immunogenicity and reactogenicity in infants

12:10-12:50 B. Kampmann: GaPs - Maternal - infant pertussis immunization study in the Gambia

12:50-13:00 wrap-up clinical studies:Lessons learned from the maternal and infant vaccination studies

13:00 - 14:00 Lunch & Coffee Break

14:00 - 15:45 Chair: Andrew Gorringe: session III:

Immune response assays

14:00-14:35 J. van Dongen: Dissection of cellular immune responses

14:35-15:00 C. van Els: What’s key in driving and maintaining human B. pertussis antigen-specific T cell memory?

15:00-15:30 A. Gorringe: Quantity and function of antibody responses to B. pertussis

15:30-15:45 J. Froberg: Insights into the circulation of B. pertussis induced in aP-vaccinated populations

15:45 - 16:15 Coffee Break

16:15 - 16:30 Opening Ceremony

16:30 - 17:15 Keynote - Camille Locht:

A journey of 40 years in research on Bordetella pertussis

17:30 - 20:00 Welcome Reception

Day Two: Tuesday June 25, 2024

9:00 - 10:30 Epi/Clin I Chair: Edwards

Update on the Global Epidemiology of Pertussis after COVID

9:00 M. Kaczmarek, ECDC

9:15 K. Fabiánová, CZ

9:30 H. Campbell, UK

9:45 S. Hariri, USA

10:00 Beard Australia

10:15 S. Walaza, SAR

10:30 - 11:00 Coffee Break

on-line - 11:00 T. Dalby, DK

on-line - 11:15 E. Montilla Colombia

11:30 - 13:00 Biol/Path I Chair: Merkel

Baboon and Human Volunteer Challenge Model studies

11:30 R. LeGrand: The baboon challenge model studies in France

11:45 T.J. Merkel: Update on the Development and Use of the baboon Pertussis Challenge Model

12:00 R.C. Read: Southampton Human Volunteer Challenge Studies update

12:10 M.S. ElSherif: Human Volunteer Challenge Model studies in Canada

12:35 Wrap-up discussion (25 min)

13:00 - 14:00 Lunch and Coffee

14:00 - 16:00 On-site poster session I

14:00 - 14:30 selected poster flash talks

14:30 - 16:00 poster viewing snacks and coffee

16:00 - 18:00 Imm/Vacc I Chair: Gestal

Immune mechanisms and vaccines

16:00 Noviello/Gbesemethe: Final phase 2b study analysis of the live atenuated BPZE1 vaccine in a challenge of healthy adults study

16:25 P. Dubey: Optimizing antigens-adjuvants-administration to elicit sustained mucosal immunity against Bordetella

16:50 K. Scanlon: Cooperative defense strategy or adverse host response? Understanding early life responses to Bordetella pertussis

17:15 C. Sedney: Pertussis toxin disrupts neonatal neutrophil-mediated control of Bordetella pertussis

17:30 F. Moosa: Bordetella pertussis antibody dynamics in a household cohort study (PHIRST)

17:45 C. Ní Chasaide: Acellular pertussis vaccines induce IL-10-secreting regulatory T cells, which suppress tissue-resident memory T cells that protect against nasal infection with Bordetella pertussis.

18:00 - 18:30 Break

18:30 - 19:30 Virtual poster session I

Day Three: Wednesday June 26, 2024

9:00 - 10:30 Biol/Path II Chair: Kamanova

Biology and pathogenesis

9:00 M. E. Rodriguez: Surviving diversity: Adaptation of Bordetella pertussis to varied intracellular environments

9:25 R. Deora: Bps Polysaccharide: A Critical Driver of Bordetella pertussis Pathogenesis in Mouse and Human Models

9:50 J. Kamanova: The quirky quirks of Bordetella Type III Secretion System: Understanding its Components and Purpose

10:10 M. Gollan: Orphan B Subunits: A Novel Type of Adhesins Vital for B. pertussis Colonization

10:20 D. Osmani: Gene Regulation in Bordetella pertussis under Nasal Temperature Mimicking Conditions

10:30 - 11:00 Coffee Break

11:00 - 13:00 Imm/Vacc II Chair: Dubey

Immune mechanisms and vaccines

11:00 M. C. Gestal: The secret role of eosinophils during Bordetella bronchiseptica infection

11:25 A. Sette: Adaptive immunity to B. pertussis in vaccination and infection

on-line - 11:50 C. Skerry: Immune determinants of long-term pulmonary health following infection

12:15 B. Creech: Immunologic Profiling of the Infant Immune Response to Whole-Cell and Acellular Pertussis Vaccines

12:30 McAlister: Impact of repeat maternal Tdap boosting on infants with variable primary pertussis vaccination schedules

12:45 J. Brummelman: Pertussis Booster Vaccination in Four Age Groups Reveals Different Shaping of Memory T Cell Responses Related to Primary-Vaccine Background

13:00 - 14:00 Lunch and Coffee

14:00 - 15:00 Evol/Gen Chair: Preston

Evolution and genomics

14:00 V. Bouchez: Bordetella pertussis vaccines drive the evolution of Bordetella parapertussis

14:20 S. Cameron: Exploration of B. pertussis adaptation using GWAS and comparative genomics

14:40 D. Hinton: sRNA downregulation of a sigma54 transcriptional activator and transporters in the virulence mode of B. pertussis

15:00 - 16:00 Epi/Clin III - Chair: Skoff

Maternal immunization

15:00 Skoff US

15:15 Campbell UK

15:30 Wood AUS

15:45 Bolotin CA

16:00 - 20:00 Guided tour of Prague - sightseeing

20:00 - 22:00 Conference dinner

Day Four: Thursday June 27, 2024

9:00 - 10:30 Biol/Path III Chair: Harvill

Biology and pathogenesis

9:00 T. Nicholson: Comparative virulence and antimicrobial resistance of B. bronchiseptica isolates from primates and swine in US

9:20 E. Harvill: Natural History of the Bordetella genus

9:40 F. Sisti: The second messenger c-di-GMP in Bordetella

10:00 B. Vecerek: Global Hfq-mediated RNA interactome of Bordetella pertussis

10:20 D. Rickert: Rethinking TCT: A novel role in Bordetella immune evasion

10:30 - 11:00 Coffee Break

11:00 - 13:00 Struct/Tox - Chair: Mattoo

Structure - Function of Virulence factors

11:00 J. McLellan: Structure-based Vaccine Antigen Design: Applications to Bordetella

11:30 S. Mattoo: Fic-mediated GMPylation: Discovery of a Bordetella Fic protein with guanylyltransferase activity

on-line - 11:50 C. Hayes: Bordetella FhaB delivers its C-terminal domain into host cells to augment adhesion

12:10 L. Bumba: A multifaceted role of filamentous hemagglutinin in the virulence of Bordetella

12:30 H. Li: Vectorial series templated folding of RTX domain of adenylyl cyclase toxin

12:50 M. Zmuda: The Bordetella effector protein BteA induces host cell death by disruption of calcium homeostasis

13:00 - 14:00 Lunch

14:00 - 16:00 On-site poster session II

14:00 - 14:30 selected poster flash talks

14:30 - 16:00 poster viewing with snacks and coffee

16:00 - 17:00 Imm/Vacc III - Chair: Mills

Immune mechanisms and vaccines

16:00 D. Diavatopoulos: Systems immunology analysis of pertussis vaccination responses

16:25 F.H. Damron: mRNA vaccines and adjuvants

16:50 D. Hozbor: Outer membrane vesicles: A bacterial-derived platform for biomedical application

17:15 - 17:45 Career Development Panel (Cavell, Scanlon) Panel TBD

17:45 - 18:15 International Bordetella Society Townhall

18:15 - 18:30 Break

18:30 - 19:30 Virtual poster session II

Day Five: Friday June 28, 2024

9:00 Keynote - K.H.G. Mills: T cell-inducing vaccines that prevent nasal infection with Bordetella pertussis and its consequences

9:45 - 10:30 Biol/Path IV - Chair: Scanlon

Biology and pathogenesis

on-line - 9:45 F. Jacob-Dubuisson: Characterization of a new virulence-regulated operon of B. pertussis

10:10 L. Coutte: Complex regulation by the BvgAS/RisAK system

10:30 - 11:00 Coffee Break

11:00 - 12:00 Epi/Clin IV - Chair: Rohani

Modeling of vaccination impact

11:00 M. Fitzpatrick: Modeling the impact of current and next-generation pertussis vaccines

11:15 J. Toubiana: Unraveling the effects of acellular vaccination on pertussis epidemiology and disease severity in France

11:30 M. Briga: Maternal pertussis immunization and the blunting of routine vaccine effectiveness

11:45 P. Rohani: Epidemiology of pertussis in Sweden

12:00-13:00 Imm/Vacc IV - Locht/Damron

Vaccine Industry Roundtable

Dynavax, Moderna, ILiaD, GSK, Sanofi, BioNet Asia

13:00 - 13:15 Xin-Xing Gu NIAID NIH Pertussis research resources

13:20 - 13:30 Closing of the conference

13:30 Lunch to go and departures

Sponsors

Local organizers: Peter Šebo, Ivana Malcová, Jana Kamanová & Branko Večerek

Location

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