Meeting schedule at a glance (Excel file)
Day One: Monday June 24, 2024
8:00 - 9:00 Registration opens
9:00 - 15:30 Lessons learned from PERISCOPE
9:00-9:15 D. Diavatopoulos: The IMI-2 EU Project PERISCOPE
9:15 - 10:30 Chair: D. Diavatopulos - session I: Challenge Models
9:15-10:05 R. C. Read: Human Volunteer Challenge Studies
10:05-10:30 R. Le Grand: Baboon challenge model studies
10:30 - 11:00 Coffee Break
11:00 - 13:00 Chair: Beate Kampmann session II:
Maternal and Infant Vaccination Studies
11:00-11:30 Q. He: MIFI - Maternal pertussis Immunization in Finland study
11:30-12:10 D. Kelly: AWARE - Acellular versus Whole cell pertussis vaccine - immunogenicity and reactogenicity in infants
12:10-12:50 B. Kampmann: GaPs - Maternal - infant pertussis immunization study in the Gambia
12:50-13:00 wrap-up clinical studies:Lessons learned from the maternal and infant vaccination studies
13:00 - 14:00 Lunch & Coffee Break
14:00 - 15:30 Chair: Andrew Gorringe: session III:
Immune reponse assays
14:00-14:35 J. van Dongen: Dissection of cellular immune responses
14:35-15:00 C. van Els: What’s key in driving and maintaining human B. pertussis antigen-specific T cell memory?
15:00-15:30 A. Gorringe: Quantity and function of antibody responses to B. pertussis
15:30-15:45 J. Froberg: Insights into the circulation of B. pertussis induced in aP-vaccinated populations
15:45 - 16:15 Coffee Break
16:15 - 16:30 Opening Ceremony
16:30 - 17:15 Keynote - Camille Locht:
A journey of 40 years in research on Bordetella pertussis
17:30 - 20:00 Welcome Reception
Day Two: Tuesday June 25, 2024
9:00 - 10:30 Epi/Clin I Chair: Edwards
Update on the Global Epidemiology of Pertussis after COVID
9:00 Campbell UK
9:15 Walaza South Africa
9:30 F. Moosa, South Africa
9:45 Hariri USA
10:00 Montilla Colombia
10:15 Beard Australia
10:30 - 11:00 Coffee Break
11:00 Tine Dalby: Pertussis outbreak in Denmark 2023/2024
11:15 Wrap-up DISCUSSION
11:30 - 13:00 Biol/Path I Chair: Merkel
Baboon and Human Volunteer Challenge Model studies
11:30 R. LeGrand: The baboon challenge model studies in France
11:45 T.J. Merkel: Update on the Development and Use of the baboon Pertussis Challenge Model
12:00 R.C. Read: Southampton Human Volunteer Challenge Studies update
12:10 M.S. ElSherif: Human Volunteer Challenge Model studies in Canada
12:35 Wrap-up discussion (25 min)
13:00 - 14:00 Lunch
14:00 - 15:30 On-site poster session I
15:30 selected poster flash talk ABS
15:40 selected poster flash talk ABS
15:50 selected poster flash talk ABS
16:00 - 18:00 Imm/Vacc I Chair: Gestal
Immune mechanisms and vaccines
16:00 Noviello/Gbesemethe: Final phase 2b study analysis of the live atenuated BPZE1 vaccine in a challenge of healthy adults study
16:25 TBA
16:50 P. Dubey: Optimizing antigens-adjuvants-administration to elicit sustained mucosal immunity against Bordetella
17:15 selected from abstract
17:30 selected from abstract
17:45 selected from abstract
18:00 - 18:30 Break
18:30 - 19:30 Virtual poster session I
Day Three: Wednesday June 26, 2024
9:00 - 10:30 Biol/Path II Chair: Kamanova
Biology and pathogenesis
9:00 M. E. Rodriguez: Surviving diversity: Adaptation of Bordetella pertussis to varied intracellular environments
9:25 R. Deora: Bps Polysaccharide: A Critical Driver of Bordetella pertussis Pathogenesis in Mouse and Human Models
9:50 J. Kamanova: The quirky quirks of Bordetella Type III Secretion System: Understanding its Components and Purpose
10:10 selected from abstracts
10:20 selected from abstracts
10:30 - 11:00 Coffee Break
11:00 - 13:00 Imm/Vacc II Chair: Dubey
Immune mechanisms and vaccines
11:00 M. C. Gestal: The secret role of eosinophils during Bordetella bronchiseptica infection
11:20 A. Sette: Adaptive immunity to B. pertussis in vaccination and infection
11:40 C. Skerry: Immune determinants of long-term pulmonary health following infection
12:00 selected from abstracts
12:15 selected from abstracts
12:30 selected from abstracts
12:45 selected from abstracts
13:00 - 14:00 Lunch
13:00 - 14:00 Evol/Gen Chair: Preston
Evolution and genomics
14:00 V. Bouchez: Bordetella pertussis vaccines drive the evolution of Bordetella parapertussis
14:20 S. Cameron: Exploration of B. pertussis adaptation using GWAS and comparative genomics
14:40 D. Hinton: sRNA downregulation of a sigma54 transcriptional activator and transporters in the virulence mode of B. pertussis
14:00 - 15:00 Epi/Clin III - Chair: Skoff
Maternal immunization
15:00 Skoff US
15:15 Campbell UK
15:30 Wood
15:45 Bolotin
16:00 - 20:00 Guided tour of Prague - sightseeing
20:00 - 22:00 Conference dinner
Day Four: Thursday June 27, 2024
9:00 - 10:30 Biol/Path III Chair: Harvill
Biology and pathogenesis
9:00 T. Nicholson: Comparative virulence and antimicrobial resistance of B. bronchiseptica isolatesfrom primates and swine in US
9:20 E. Harvill: Natural History of the Bordetella genus
9:40 F. Sisti: The second messenger c-di-GMP in Bordetella
10:00 B. Vecerek: Global Hfq-mediated RNA interactome of Bordetella pertussis
10:20 selected 10' form abstracts
10:30 - 11:00 Coffee Break
11:00 - 13:00 Struct/Tox - Chair: Mattoo
Structure - Function of Virulence factors
11:00 J. McLellan: Structure-based Vaccine Antigen Design: Applications to Bordetella
11:30 S. Mattoo: Fic-mediated GMPylation: Discovery of a Bordetella Fic protein with guanylyltransferase activity
11:50 C. Hayes: Bordetella FhaB delivers its C-terminal domain into host cells to augment adhesion
12:10 L. Bumba: A multifaceted role of filamentous hemagglutinin in the virulence of Bordetella
12:30 H. Li: Vectorial series templated folding of RTX domain of adenylyl cyclase toxin
12:50 selected 10' from abstracts
13:00 - 14:00 Lunch
14:00 - 15:30 On-site poster session II
15:30 Poster flash talks
15:40 Poster flash talks
15:50 Poster flash talks
16:00 - 17:00 Imm/Vacc III - Chair: Mills
Immune mechanisms and vaccines
16:00 D. Diavatopoulos: Systems immunology analysis of pertussis vaccination responses
16:20 F.H. Damron: mRNA vaccines and adjuvants
16:40 D. Hozbor: Outer membrane vesicles: A bacterial-derived platform for biomedical application
17:00 - 17:30 Career Development Panel (Cavell, Scanlon) Panel TBD
17:30 - 18:10 International Bordetella Society Townhall
18:10 - 18:30 Break
18:30 - 19:30 Virtual poster session II
Day Five: Friday June 28, 2024
9:00 Keynote - K.H.G. Mills: T cell-inducing vaccines that prevent nasal infection with Bordetella pertussis and its consequences
9:45 - 10:30 Biol/Path IV - Chair: Scanlon
Biology and pathogenesis
9:45 F. Jacob-Dubuisson: Characterization of a new virulence-regulated operon of B. pertussis
10:10 L. Coutte: Complex regulation by the BvgASR/RisAK system
10:30 - 11:00 Coffee Break
11:00 - 12:00 Epi/Clin IV - Chair: Rohani
Modeling of vaccination impact
11:00 M. Fitzpatrick: Modeling the impact of current and next-generation pertussis vaccines
11:15 J. Toubiana: Unraveling the effects of acellular vaccination on pertussis epidemiology and disease severity in France
11:30 M. Briga: Maternal pertussis immunization and the blunting of routine vaccine effectiveness
11:45 P. Rohani: Epidemiology of pertussis in Sweden
12:00-13:00 Imm/Vacc III - Locht/Damron
Vaccine Industry Roundtable
Dynavax, Moderna, ILiaD, GSK, Sanofi, BioNet Asia
13:00 - 13:15 Xin-Xing Gu NIAID NIH Pertussis research resources
13:20 - 13:30 Closing of the conference