6:30 Breakfast 8:30 KEYNOTE SPEAKER, HYMAN NIZNIK CONFERENCE Chair: Oliver Ernst Krzysztof Palczewski, University of California Irvine, USA Structural View of G Protein-Coupled Receptor Signaling in the Retinal Rod Outer Segment 9:30 Coffee Break SESSION 1: STRUCTURAL AND DYNAMIC ASPECTS OF GPCRs Chair: Oliver Ernst 9:45 Demet Arac-Ozkan, University of Chicago, USA Structure and Function of Adhesion GPCRs 10:10 Joshua Ziarek, Indiana University Bloomington, USA Molecular Mechanisms of Biased Signaling at the Angiotensin Receptor 10:35 Cheng Zhang, University of Pittsburgh, USA How GPCR structures illuminate receptor pharmacology and signaling mechanisms 11:00 Coffee Break

SESSION 2: SINGLE-MOLECULE STUDIES of GPCRs Chair: Claudiu Gradinaru 11:15 Vali Raicu, University of Wisconsin-Milwaukee, USA FRET spectrometry of GPCRs: Probing receptor quaternary structure a few oligomers at a time 11:40 Reza Vafabakhsh, Northwestern University, USA Mechanisms of Sensitivity Modulation in GPCRs 12:05 Scott Blanchard, St. Jude Children's Research Hospital, USA GPCR-mediated Signaling Deconvoluted with Single-molecule Precision 12:30 Lunch

SESSION 3: GPCR SIGNALING AND TRAFFICKING Chair: Susan George 14:00 Lauren Slosky, University of Minnesota, USA Leveraging functional selectivity and allosteric modulation in the search for addiction therapeutics 14:25 Manoj Puthenveedu, University of Michigan, USA Spatial regulation of opioid receptors 14:50 Rithwik Ramachandran, Western University, Canada Probing mechanisms of activation and signalling from tethered-ligand activated G Protein-Coupled Receptors. 15:15 Coffee Break

SESSION 4: UPDATES FROM AROUND THE LAKES Chair: Scott Prosser 15:30 Martin Audet, Université de Sherbrooke, Canada Insight into prostaglandin receptor structure and signaling 15:55 Ajith Karunarathne, University of Toledo, USA Engineering of a spectrally tuned melanopsin for subcellular optogenetics 16:20 Van Lu, Western University, Canada Bile acid-mediated signaling in human enteroendocrine cells: link between nutrition, gut microbiota and gut function Community Ressources 16:45: Yamina Berchiche Dr. GPCR Ecosystem 2.0: Collaborating Better

17:10 Poster Session #2 (even numbered posters) (even number posters should be put on during lunch break) 19:45 Dinner 21:30 Board Meeting (to discuss next retreat) – All PI’s are welcome to participate