6:30 Breakfast SESSION 5: ERIC MARSAULT DRUG DISCOVERY SYMPOSIUM Chair: Martin Audet 8:30 Michel Bouvier, Université de Montréal, Canada Shining light on GPCR subcellular functional and spatial selectivity using the ebBRET-based effector membrane translocation assay (EMTA) platform. 8:55 Laura Wingler, Duke University, USA Molecular Mechanisms of Biased Signaling at the Angiotensin Receptor 9:20 Laurent Sabbagh, Domain Therapeutics, Canada Automated large-scale signaling profiling using bioSens-All® of rare naturally occurring GPCR variants occurring in human populations 9:45 Coffee Break

SESSION 6: SYSTEM BIOLOGY OF GPCRs Chair: Stephen Ferguson 10:15 Terry Hebert, McGill University, Canada Systems biology approaches to understand GPCR signalling in cardiovascular disease 10:40 Emiliana Borrelli, University of California Irvine, USA Dopamine D2 receptor dependent control of striatal circuits 11:05 Jean Martin Beaulieu, University of Toronto, Canada Circuit selective characterization of GPCR functions using intersectional Crispr/Cas9 approaches 11:30 HUBERT VAN TOL CONFERENCE Chair: Martin Beaulieu Kirill Martemyanov, Scripps Research Florida, USA Mining GPCR signaling landscape by unbiased discovery approaches 12:30 Closing Remarks 12:45 Lunch and Farewell